Catalog No: ARP55585_P050
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ARP55585_P050
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Datasheets/ManualsPrintable datasheet for anti-FBXW8 (ARP55585_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human FBXW8
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 83%; Dog: 92%; Guinea Pig: 83%; Horse: 92%; Human: 100%; Mouse: 92%; Rabbit: 100%; Rat: 92%
Peptide SequenceSynthetic peptide located within the following region: MNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHR
Concentration0.5 mg/ml
Blocking PeptideFor anti-FBXW8 (ARP55585_P050) antibody is Catalog # AAP55585 (Previous Catalog # AAPP34146)
ReferenceTsutsumi,T., (2008) Mol. Cell. Biol. 28 (2), 743-751
Publications

Lin, P. et al. Fbxw8 is involved in the proliferation of human choriocarcinoma JEG-3 cells. Mol. Biol. Rep. 38, 1741-7 (2011). 20878477

Gene SymbolFBXW8
Gene Full NameF-box and WD repeat domain containing 8
Alias SymbolsFBW6, FBW8, FBX29, FBXW6, FBXO29
NCBI Gene Id26259
Protein NameF-box/WD repeat-containing protein 8
Description of TargetFBXW8 is a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. FBXW8 contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class.This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
Uniprot IDQ8N3Y1
Protein Accession #NP_699179
Nucleotide Accession #NM_153348
Protein Size (# AA)598
Molecular Weight67kDa
Protein InteractionsMAP4K1; CUL1; TBC1D3; CUL7; UBE2D3; SKP1; IRS1; REST; CCND1; CUL4A; DDB1; UBC; CCDC8; GORASP1; OBSL1; CCT6B; CCT2; CCT7; TRIP13; PDCD5; CUL2; VBP1; CCT3; PFDN5; NFKBIA; CCT6A; BCL3; BTRC; SKP2; HSP90AA1; HSPA4; FBXO4; FBXW8; FBXW2; MYC; RBX1; UBI4; EP300;
  1. What is the species homology for "FBXW8 Antibody - middle region (ARP55585_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit".

  2. How long will it take to receive "FBXW8 Antibody - middle region (ARP55585_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "FBXW8 Antibody - middle region (ARP55585_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "FBXW8 Antibody - middle region (ARP55585_P050)"?

    This target may also be called "FBW6, FBW8, FBX29, FBXW6, FBXO29" in publications.

  5. What is the shipping cost for "FBXW8 Antibody - middle region (ARP55585_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "FBXW8 Antibody - middle region (ARP55585_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "FBXW8 Antibody - middle region (ARP55585_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "67kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "FBXW8 Antibody - middle region (ARP55585_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "FBXW8"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "FBXW8"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "FBXW8"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "FBXW8"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "FBXW8"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "FBXW8"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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