Catalog No: ARP30627_P050
Price: $0.00
SKU
ARP30627_P050
Availability: Domestic: within 1-2 days delivery | International: 1-2 days
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Datasheets/ManualsPrintable datasheet for anti-FAS (ARP30627_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Pig
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human FAS
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceHuman: 100%; Pig: 80%
Peptide SequenceSynthetic peptide located within the following region: KKEAYDTLIKDLKKANLCTLAEKIQTIILKDITSDSENSNFRNEIQSLV
Concentration0.5 mg/ml
Blocking PeptideFor anti-FAS (ARP30627_P050) antibody is Catalog # AAP30627 (Previous Catalog # AAPP01280)
Gene SymbolFAS
Gene Full NameFas (TNF receptor superfamily, member 6)
Alias SymbolsAPT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6
NCBI Gene Id355
Protein NameTumor necrosis factor receptor superfamily member 6
Description of TargetFAS is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
Uniprot IDP25445
Protein Accession #NP_000034
Nucleotide Accession #NM_000043
Protein Size (# AA)335
Molecular Weight36kDa
Protein InteractionsFADD; CAV1; FAS; APOA5; TMX1; UBQLN1; MBD4; TP63; TCAP; BAG6; UBC; HNRNPC; GADD45A; CCND3; ATP6V0B; SQSTM1; Ube2i; PRAM1; RARA; PML; DAXX; FASLG; TRADD; MAP3K5; BMX; Traf1; FAF1; FAF2; TRAF3; KRIT1; TNF; BRE; LRIF1; FEM1B; FBF1; FAIM2; CASP8AP2; C14orf1;
  1. What is the species homology for "FAS Antibody - middle region (ARP30627_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Pig".

  2. How long will it take to receive "FAS Antibody - middle region (ARP30627_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "FAS Antibody - middle region (ARP30627_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "FAS Antibody - middle region (ARP30627_P050)"?

    This target may also be called "APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6" in publications.

  5. What is the shipping cost for "FAS Antibody - middle region (ARP30627_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "FAS Antibody - middle region (ARP30627_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "FAS Antibody - middle region (ARP30627_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "36kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "FAS Antibody - middle region (ARP30627_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "FAS"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "FAS"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "FAS"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "FAS"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "FAS"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "FAS"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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