EZH1 Recombinant Protein (OPCD00861)

Catalog No: OPCD00861

EZH1 Recombinant Protein (OPCD00861) using SDS-PAGE

EZH1 Recombinant Protein (OPCD00861) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Subcellular Location: Nucleus
  Isoelectric Point: 8.1
  Residues: Pro559-Leu747
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: EZH1
• Gene Full Name: enhancer of zeste 1 polycomb repressive complex 2 subunit
• Alias Symbols: enhancer of zeste homolog 1;ENX-2;histone-lysine N-methyltransferase EZH1;KMT6B.
• NCBI Gene Id: 2145
• Protein Name: Histone-lysine N-methyltransferase EZH1
• Description of Target: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
• Uniprot ID: Q92800
• Protein Accession #: NP_001308008.1
• Nucleotide Accession #: NM_001321079.1
• Protein Size (# AA): Pro559~Leu747
• Molecular Weight: 25kDa