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Catalog No: OPCD02876
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OPCD02876
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Datasheets/ManualsPrintable datasheet for EGR1 Recombinant Protein (OPCD02876)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationSubcellular Location: Nucleus
Predicted Isoelectric Point: 10.5
::Residues: Gln282-Ser433
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 97%
SourceE.coli
TagN-terminal His Tag
Gene SymbolEGR1
Gene Full Nameearly growth response 1
Alias SymbolsAT225;early growth response protein 1;EGR-1;G0S30;KROX-24;nerve growth factor-induced protein A;NGFI-A;TIS8;transcription factor ETR103;transcription factor Zif268;ZIF-268;zinc finger gene 225;zinc finger protein 225;zinc finger protein Krox-24;ZNF225.
NCBI Gene Id1958
Protein NameEarly growth response protein 1
Description of TargetTranscriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity).
Uniprot IDP18146
Protein Accession #NP_001955.1
Nucleotide Accession #NM_001964.2
Protein Size (# AA)Gln282~Ser433
Molecular Weight22kDa
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