DSTN Antibody - N-terminal region (ARP48307_P050)

Catalog No: ARP48307_P050

WB Suggested Anti-DSTN Antibody Titration: 0.2-1 ug/ml
Positive Control: MCF7 cell lysateDSTN is strongly supported by BioGPS gene expression data to be expressed in Human MCF7 cells

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DSTN
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 92%
• Peptide Sequence: Synthetic peptide located within the following region: ASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEE
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-DSTN (ARP48307_P050) antibody is Catalog # AAP48307 (Previous Catalog # AAPS23711)
• Sample Type Confirmation:

  DSTN is strongly supported by BioGPS gene expression data to be expressed in MCF7

• Reference: Estornes,Y., (2007) Int. J. Cancer 121 (10), 2162-2171

Target Info

• Gene Symbol: DSTN
• Gene Full Name: Destrin (actin depolymerizing factor)
• Alias Symbols: ADF, ACTDP, HEL32, bA462D18.2
• NCBI Gene Id: 11034
• Protein Name: Destrin
• Description of Target: DSTN belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. It is the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin).The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene.
• Uniprot ID: P60981
• Protein Accession #: NP_006861
• Nucleotide Accession #: NM_006870
• Protein Size (# AA): 165
• Molecular Weight: 18kDa
• Protein Interactions: CFL2; ACTG1; ACTB; TAX1BP1; UBC; MDM2; EED; NPM1; ACTA1; SMAD9; STMN2; SEC24A; PDLIM5; DNPH1; LAMTOR5; DPP3; PIEZO1; PUM1; NMI; UBA3; LIMD1; VCP; UBE2B; TTC1; TSTA3; TPM2; STAT6; SP100; ITSN1; SGTA; SRSF2; S100A9; RNH1; PXN; PEX19; PTMS; PTMA; PSMD9; MYH1