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Catalog No: OPCD02739
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OPCD02739
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Datasheets/ManualsPrintable datasheet for DISC1 Recombinant Protein (OPCD02739)
Product Info
Predicted Species ReactivityRat|Rattus norvegicus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Glu151-Gln340
::Subcellular Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His Tag
Gene SymbolDisc1
Gene Full NameDISC1 scaffold protein
Alias Symbolsdisrupted in schizophrenia 1 homolog.
NCBI Gene Id307940
Protein NameDisrupted in schizophrenia 1 homolog
Description of TargetInvolved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.
Uniprot IDQ810H6
Protein Accession #NP_783186.2
Nucleotide Accession #NM_175596.2
Protein Size (# AA)Glu151~Gln340
Molecular Weight27kDa
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