DISC1 Antibody (OACA10117)

Catalog No: OACA10117

Immunofluorescent analysis of Hela cells at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Western Blot
Positive WB detected in: SH-SY5Y whole cell lysate,Hela whole cell lysate
All lanes: DISC1 antibody at 2ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/5,0000 dilution
Predicted band size: 94,92,74,39,83,63,61,76,73,38,22 kDa
Observed band size: 94,92,38 kDa

Western Blot
Positive WB detected in: SH-SY5Y whole cell lysate,Hela whole cell lysate
All lanes: DISC1 antibody at 2ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/5,0000 dilution
Predicted band size: 94,92,74,39,83,63,61,76,73,38,22 kDa
Observed band size: 94,92,38 kDa

Immunofluorescent analysis of Hela cells at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Western blot
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human Disrupted in schizophrenia 1 protein (99-325AA)
• Purification: Protein G Purified
• Preservative: 0.03% Proclin 300
• Formulation: 50% Glycerol, 0.01M PBS, PH 7.4
• Purity: >95%

Target Info

• Gene Symbol: DISC1
• Gene Full Name: DISC1 scaffold protein
• Alias Symbols: C1orf136;disrupted in schizophrenia 1 protein;SCZD9.
• NCBI Gene Id: 27185
• Protein Name: Disrupted in schizophrenia 1 protein
• Description of Target: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.
• Uniprot ID: Q9NRI5
• Protein Accession #: NP_001012975
• Nucleotide Accession #: NM_001012957