DISC1 Antibody - C-terminal region (OAAB11126)

Catalog No: OAAB11126

Size:400ul

DISC1 Antibody (C-term) (Cat. #OAAB11126) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the DISC1 antibody detected the DISC1 protein (arrow).

DISC1 Antibody (C-term) (Cat. #OAAB11126)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DISC1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

DISC1 Antibody (C-term) (Cat. #OAAB11126) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB, FC, IHC
• Additional Information: Precautions: DISC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
  Function: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation
  Cellular Location: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity) Note=Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. Colocalizes with PCNT at the centrosome
  Tissue Location: Ubiquitous. Highly expressed in the dentate gyrus of the hippocampus. Also expressed in the temporal and parahippocampal cortices and cells of the white matter
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This DISC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 701-728 amino acids from the C-terminal region of human DISC1.
• Predicted Homology Based on Immunogen Sequence: Human
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Application Info: WB: 1:1000
  FC: 1:10~50
  IHC-P: 1:10~50

Target Info

• Gene Symbol: DISC1
• Alias Symbols: SCZD9, C1orf136
• NCBI Gene Id: 27185
• Protein Name: Disrupted in schizophrenia 1 protein
• Description of Target: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Uniprot ID: Q9NRI5
• Protein Accession #: NP_001012975.1
• Molecular Weight: 93611 Da