DcR1 Antibody (OAPB00079)

Catalog No: OAPB00079 (Formerly GWB-409B26)

Size:100UG

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Western blot analysis of DcR1 in HeLa whole cell lysate with DcR1 antibody (ED) at 1:500 dilution.

Immunofluorescence of DcR1 in Hela cells with DcR1 antibody at 20 ug/mL.

Immunocytochemistry of DcR1 in HeLa cells with DcR1 antibody at 10 μg/mL.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid. DcR1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Western blot
  Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.
• Reconstitution and Storage: DcR1 antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Immunogen: DcR1 antibody was raised against a peptide corresponding to amino acids in a extracellular domain of human DcR1 precursor. The immunogen is located within amino acids 140 - 190 of DcR1.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human; Mouse; Rat
• Concentration: 1 mg/ml
• Blocking Peptide: For anti-DcR1 antibody is Catalog # OEPB02206
• Application Info: DcR1 antibody can be used for detection of DcR1 by Western blot at 1:500 to 1:1000 dilution. An approximate 65 kDa band can be detected (6). It is human, mouse, and rat reactive. (Optimal dilution should be determined by user)
• Reference: Pan G; O'Rourke K; Chinnaiyan et al.. The receptor for the cytotoxic ligand TRAIL. Science; 1997;276:111-113;Pan G, Ni J, Wei YF, et al. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 1997;277:815-8 ;Sheridan JP, Marsters SA, Pitti RM, et al. A. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 1997;277:818-21 ;Degli-Esposti MA, Smolak PJ, Walczak H, et al, Smith CA. Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. J Exp Med 1997;186(7):1165-70

Target Info

• Gene Symbol: TNFRSF10C
• Gene Full Name: TNF receptor superfamily member 10c
• Alias Symbols: antagonist decoy receptor for TRAIL/Apo-2L;CD263;cytotoxic TRAIL receptor-3;DCR1;DCR1-TNFR;decoy receptor 1;decoy TRAIL receptor without death domain;LIT;lymphocyte inhibitor of TRAIL;TNF-related apoptosis-inducing ligand receptor 3;TRAIL receptor without an intracellular domain;TRAILR3;TRAIL-R3;TRID;tumor necrosis factor receptor superfamily member 10C;tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain.
• NCBI Gene Id: 8794
• Protein Name: Homo sapiens decoy receptor 1 (DcR1) mRNA, complete cds|Tumor necrosis factor receptor superfamily member 10C
• Description of Target: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
• Uniprot ID: O14798
• Protein Accession #: AF012536
• Nucleotide Accession #: https://www.ncbi.nlm.nih.gov/nuccore/AF012536
• Molecular Weight: 65 kDa