CAMKK2(calcium/calmodulin-dependent protein kinase kinase 2, beta) Antibody

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Catalog#

Accession #

Size

Price

Qty

ARP53184_P050

NP_705720

50µg

$289.00

Description:
CAMKK2 is a calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. CAMKK2 seems to be involved in hippocampal activation of CREB1.The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Seven transcript variants encoding six distinct isoforms have been identified for this gene. Additional splice variants have been described but their full-length nature has not been determined. The identified isoforms exhibit a distinct ability to undergo autophosphorylation and to phosphorylate the downstream kinases.

Species Reactivity:
Human

Gene Symbol:
CAMKK2

Alias Symbols:
CAMKK; CAMKKB; KIAA0787; MGC15254

Peptide ID:
P36322

ELISA titre using peptide based assay:
1:62500

Search Keyword:
CAMKK2, CAMKK; CAMKKB; KIAA0787; MGC15254, NP_705720

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Antigen Specificity:
Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human CAMKK2 with an internal ID of P36322

Reconstitution and Storage:
Antibody is lyophilized from PBS buffer with 2% sucrose. Add 50 μl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.

Key Reference:
Erhardt,A., J Affect Disord 101 (1-3), 159-168 (2007)

Quality Control:
Rabbit Ig G is purified by peptide affinity chromatography method.

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. For research use only not for diagnostic, human, or veterinary use.

Western Blot
Suggested dilution at 1µg/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as second antibody.

Immunoblot

ARP53184-QC26528-WB.jpg

Protein Accession#	Swissprot Id	Nucleotide Accession#	Protein Size	Molecular Weight
NP_705720	Q96RR4	NM_153500	498	55kDa