COL1A2 Antibody - middle region (ARP58441_P050)

Catalog No: ARP58441_P050

WB Suggested Anti-COL1A2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Human Liver

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human COL1A2
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 93%; Goat: 79%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 79%; Rabbit: 86%; Rat: 100%; Zebrafish: 85%
• Peptide Sequence: Synthetic peptide located within the following region: PGSVGPAGPRGPAGPSGPAGKDGRTGHPGTVGPAGIRGPQGHQGPAGPPG
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-COL1A2 (ARP58441_P050) antibody is Catalog # AAP58441 (Previous Catalog # AAPP34554)
• Enhanced Validation:

  WB	Y
  SPR
  YCHAROS

• Reference: Huang,H., (er) Community Dent Oral Epidemiol (2008) In press

Target Info

• Gene Symbol: COL1A2
• Gene Full Name: Collagen, type I, alpha 2
• Alias Symbols: OI4, EDSCV, EDSARTH2
• NCBI Gene Id: 1278
• Protein Name: Collagen alpha-2(I) chain
• Description of Target: COL1A2 is the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity.This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Uniprot ID: P08123
• Protein Accession #: NP_000080
• Nucleotide Accession #: NM_000089
• Protein Size (# AA): 1366
• Molecular Weight: 129 kDa
• Protein Interactions: UBQLN1; SGTA; PDGFB; PDGFA; COL1A1; PAN2; LIG4; MYOC; SHBG; UBC; MMP9; COL5A3; CD44; APP; P4HB; ITGA2B; TGFBI; LUM; BGN; VWF; ITGA2; SPARC; CD36; ITGB3; FN1; DCN; CD93;