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Catalog No: ARP44580_P050
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ARP44580_P050
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Datasheets/ManualsPrintable datasheet for anti-CLSTN1 (ARP44580_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the N terminal region of human CLSTN1
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 82%; Dog: 92%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%
Peptide SequenceSynthetic peptide located within the following region: KPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEI
Concentration0.5 mg/ml
Blocking PeptideFor anti-CLSTN1 (ARP44580_P050) antibody is Catalog # AAP44580 (Previous Catalog # AAPP12096)
Gene SymbolCLSTN1
Gene Full NameCalsyntenin 1
Alias SymbolsCST-1, CSTN1, CDHR12, PIK3CD, ALC-ALPHA, XB31alpha, alcalpha1, alcalpha2
NCBI Gene Id22883
Protein NameCalsyntenin-1
Description of TargetCLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment,CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.
Uniprot IDO94985
Protein Accession #NP_001009566
Nucleotide Accession #NM_001009566
Protein Size (# AA)981
Molecular Weight110kDa
Protein InteractionsMDM2; BAHCC1; SETDB1; SLK; TRIP12; MCM3AP; UBC; KLC2; CLSTN1; TOPBP1; APBA2; APBB1; KIF2A; KLC1; PRNP; COL17A1; PSEN1; APP;
  1. What is the species homology for "CLSTN1 Antibody - N-terminal region (ARP44580_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish".

  2. How long will it take to receive "CLSTN1 Antibody - N-terminal region (ARP44580_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "CLSTN1 Antibody - N-terminal region (ARP44580_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "CLSTN1 Antibody - N-terminal region (ARP44580_P050)"?

    This target may also be called "CST-1, CSTN1, CDHR12, PIK3CD, ALC-ALPHA, XB31alpha, alcalpha1, alcalpha2" in publications.

  5. What is the shipping cost for "CLSTN1 Antibody - N-terminal region (ARP44580_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "CLSTN1 Antibody - N-terminal region (ARP44580_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "CLSTN1 Antibody - N-terminal region (ARP44580_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "110kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "CLSTN1 Antibody - N-terminal region (ARP44580_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "CLSTN1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "CLSTN1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "CLSTN1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "CLSTN1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "CLSTN1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "CLSTN1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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