CIITA Antibody - middle region (ARP37976_P050)

Catalog No: ARP37976_P050

WB Suggested Anti-CIITA Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Human Liver

Host: Rabbit
Target Name: CIITA
Sample Tissue: Human OVCAR-3 Whole Cell
Antibody Dilution: 1ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CIITA
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 79%; Dog: 86%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 86%; Pig: 100%; Rabbit: 93%; Rat: 93%
• Peptide Sequence: Synthetic peptide located within the following region: YNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSVQEHLQQQDSRISLR
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-CIITA (ARP37976_P050) antibody is Catalog # AAP37976 (Previous Catalog # AAPP23272)
• Reference: Lovkvist,H., (er) Eur. J. Hum. Genet. (2008) In press

Target Info

• Gene Symbol: CIITA
• Gene Full Name: Class II, major histocompatibility complex, transactivator
• Alias Symbols: C2TA, NLRA, MHC2TA, CIITAIV
• NCBI Gene Id: 4261
• Protein Name: MHC class II transactivator
• Description of Target: CIITA is a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the 'master control factor' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the 'master control factor' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Uniprot ID: P33076
• Protein Accession #: NP_000237
• Nucleotide Accession #: NM_000246
• Protein Size (# AA): 1130
• Molecular Weight: 123kDa
• Protein Interactions: PSMC5; CUL3; TAF9; GTF2B; PSMC3; PSMC2; SIN3B; HDAC2; GSK3B; HDAC5; HDAC4; SMARCA4; RFX5; HDAC1; ZXDC; TAF6; KAT2B; RFXANK; NCOA1; XPO1; PRKACA; NFYB; MAPK3; MAPK1; CDK1; HIST4H4; POLR2A; ACTB;