Catalog No: AVARP03005_T100
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AVARP03005_T100
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Datasheets/ManualsPrintable datasheet for anti-CDK6 (AVARP03005_T100) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Cow, Dog, Horse, Pig, Rabbit
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the C terminal region of human CDK6
PurificationProtein A purified
Predicted Homology Based on Immunogen SequenceCow: 84%; Dog: 84%; Horse: 84%; Human: 100%; Mouse: 76%; Pig: 84%; Rabbit: 84%
Peptide SequenceSynthetic peptide located within the following region: LLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
Concentration1.0 mg/ml
Blocking PeptideFor anti-CDK6 (AVARP03005_T100) antibody is Catalog # AAP30155 (Previous Catalog # AAPS08603)
Sample Type Confirmation

CDK6 is supported by BioGPS gene expression data to be expressed in Jurkat

ReferenceMendrzyk,F., (2005) J. Clin. Oncol. 23 (34), 8853-8862
Gene SymbolCDK6
Gene Full NameCyclin-dependent kinase 6
Alias SymbolsMCPH12, PLSTIRE
NCBI Gene Id1021
Protein NameCyclin-dependent kinase 6
Description of TargetCDK6 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.
Uniprot IDQ00534
Protein Accession #NP_001250
Nucleotide Accession #NM_001259
Protein Size (# AA)326
Molecular Weight37kDa
Protein InteractionsPSMA3; DAB1; CDKN2D; CDKN2C; CDKN2B; CCND3; UBC; CCND2; AMY2A; CDKN2A; CDK6; PIGR; DMBT1; WDR33; CDKL3; RB1; CDK4; UCHL1; PML; NUMA1; NFATC3; MYC; MLLT3; MEF2D; MCM2; ISL1; HSP90AA1; HSF1; FOXO3; FOXM1; EZH2; ELK1; DDIT3; ATF6B; CDKN1A; CDC6; CCND1; ZSCAN
  1. What is the species homology for "CDK6 Antibody - C-terminal region (AVARP03005_T100)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Cow, Dog, Horse, Pig, Rabbit".

  2. How long will it take to receive "CDK6 Antibody - C-terminal region (AVARP03005_T100)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "CDK6 Antibody - C-terminal region (AVARP03005_T100)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "CDK6 Antibody - C-terminal region (AVARP03005_T100)"?

    This target may also be called "MCPH12, PLSTIRE" in publications.

  5. What is the shipping cost for "CDK6 Antibody - C-terminal region (AVARP03005_T100)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "CDK6 Antibody - C-terminal region (AVARP03005_T100)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "CDK6 Antibody - C-terminal region (AVARP03005_T100)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "37kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "CDK6 Antibody - C-terminal region (AVARP03005_T100)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "CDK6"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "CDK6"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "CDK6"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "CDK6"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "CDK6"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "CDK6"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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