Catalog No: ARP30788_P050
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ARP30788_P050
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Datasheets/ManualsPrintable datasheet for anti-CCR5 (ARP30788_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Cow, Pig
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human CCR5
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 92%; Human: 100%; Pig: 100%
Peptide SequenceSynthetic peptide located within the following region: SHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKK
Concentration0.5 mg/ml
Blocking PeptideFor anti-CCR5 (ARP30788_P050) antibody is Catalog # AAP30788 (Previous Catalog # AAPP01451)
ReferenceCatano,G., (2008) J. Infect. Dis. 198 (1), 72-80
Gene SymbolCCR5
Gene Full NameChemokine (C-C motif) receptor 5 (gene/pseudogene)
Alias SymbolsCKR5, CCR-5, CD195, CKR-5, CCCKR5, CMKBR5, IDDM22, CC-CKR-5
NCBI Gene Id1234
Protein NameC-C chemokine receptor type 5
Description of TargetCCR5 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this protein was also detected in a promyeloblastic cell line, suggesting that CCR5 may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.
Uniprot IDP51681
Protein Accession #NP_000570
Nucleotide Accession #NM_000579
Protein Size (# AA)352
Molecular Weight41kDa
Protein InteractionsCST9L; IL24; ETV5; CTBP2; PSMA5; CCL3L3; ARL6IP5; PRAF2; DNM2; CCL8; STAT5A; CCL3L1; CCL16; CCL14; CCL13; CCR5; CCR2; PTK2B; CCL11; GNAQ; PTK2; STAT1; TXK; CCL5; CD4; CCL4; CCL3; CXCR4; CCL7; CCL2; LCK; JAK2; JAK1; GNAI3; GNAI2; GNAO1; GNAI1; ORM1; ADRBK2
  1. What is the species homology for "CCR5 Antibody - middle region (ARP30788_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Cow, Pig".

  2. How long will it take to receive "CCR5 Antibody - middle region (ARP30788_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "CCR5 Antibody - middle region (ARP30788_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "CCR5 Antibody - middle region (ARP30788_P050)"?

    This target may also be called "CKR5, CCR-5, CD195, CKR-5, CCCKR5, CMKBR5, IDDM22, CC-CKR-5" in publications.

  5. What is the shipping cost for "CCR5 Antibody - middle region (ARP30788_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "CCR5 Antibody - middle region (ARP30788_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "CCR5 Antibody - middle region (ARP30788_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "41kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "CCR5 Antibody - middle region (ARP30788_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "CCR5"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "CCR5"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "CCR5"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "CCR5"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "CCR5"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "CCR5"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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