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CCR5 antibody - middle region (ARP30788_P050)

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100 ul
$289.00
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Gene Symbol:
CCR5
NCBI Gene Id:
1234
Official Gene Full Name:
Chemokine (C-C motif) receptor 5 (gene/pseudogene)
Protein Name:
C-C chemokine receptor type 5
Swissprot Id:
P51681
Protein Accession #:
NP_000570
Nucleotide Accession #:
NM_000579
Alias Symbols:
CC-CKR-5, CCCKR5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
Description of Target:
CCR5 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this protein was also detected in a promyeloblastic cell line, suggesting that CCR5 may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.
Protein Size (# AA):
352
Molecular Weight:
41kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CCR5.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CCR5.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human CCR5
Species Reactivity:
Cow, Human, Pig
Predicted Homology Based on Immunogen Sequence:
Cow: 92%; Human: 100%; Pig: 100%
Complete computational species homology data:
Anti-CCR5 (ARP30788_P050)
Peptide Sequence:
Synthetic peptide located within the following region: SHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKK
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
CST9L; IL24; ETV5; CTBP2; PSMA5; CCL3L3; ARL6IP5; PRAF2; DNM2; CCL8; STAT5A; CCL3L1; CCL16; CCL14; CCL13; CCR5; CCR2; PTK2B; CCL11; GNAQ; PTK2; STAT1; TXK; CCL5; CD4; CCL4; CCL3; CXCR4; CCL7; CCL2; LCK; JAK2; JAK1; GNAI3; GNAI2; GNAO1; GNAI1; ORM1; ADRBK2
Blocking Peptide:
For anti-CCR5 (ARP30788_P050) antibody is Catalog # AAP30788 (Previous Catalog # AAPP01451)
Datasheets / Downloads:
Printable datasheet for anti-CCR5 (ARP30788_P050) antibody
Target Reference:
Catano,G., (2008) J. Infect. Dis. 198 (1), 72-80

Product Protocols: CCR5 antibody tested with Human Fetal Heart Tissue (ARP30788_P050)

Aviva Systems Biology is the original manufacturer of this CCR5 antibody (ARP30788_P050)

Click here to view the CCR5 antibody Western Blot Protocol

Product Datasheet Link: CCR5 antibody (ARP30788_P050)

WB Suggested Anti-CCR5 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Fetal Heart

Western Blot image:


Description of Target: CCR5 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this protein was also detected in a promyeloblastic cell line, suggesting that CCR5 may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.

Questions pertaining to this data can be directed to techsupport@avivasysbio.com

Aviva Systems Biology’s CCR5 antibody (ARP30788_P050) has been tested using other cell lysates and tissues. To obtain more data about this antibody please email us at info@avivasysbio.com.

To order by phone call us at (888) 880-0001, fax us at (858) 552-6975 or send an email to info@avivasysbio.com. Aviva manufactures this antibody so we can offer the best price. Please contact us to request pricing information.

All of Aviva’s products are guaranteed for the applications and experimental sample types mentioned in the datasheet below. Are you curious if this product will work for you? Please contact us at techsupport@avivasysbio.com

 
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