NR3C2(nuclear receptor subfamily 3, group C, member 2) Antibody

• Catalog#: ARP45599_T100
• Accession#: NP_000892
• Size: 100µg

Description: 
NR3C2 is a receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. It binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.

Species Reactivity:  Human   Gene Symbol:  NR3C2   Alias Symbols:  MCR; MGC133092; MLR; MR   Peptide ID:  P11878   ELISA titre using peptide based assay:  1:312500   Search Keyword:  NR3C2, NM_000901, NP_000892, P08235   Click Here to view more information (protein size, molecular weight, etc)

Antigen Specificity:  Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human NR3C2 with an internal ID of P11878  Reconstitution and Storage:  Antibody is lyophilized from PBS buffer with 2% sucrose. Add 100 μl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.  Key Reference:  Liu,G., (2006) Biochem. Biophys. Res. Commun. 342 (4), 1291-1296  Quality Control:  Rabbit IgG purified by protein A chromatography.  Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. For research use only not for diagnostic, human, or veterinary use.

Western Blot Suggested dilution at 1.25µg/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as second antibody. Immunoblot ARP45599-QC13877-WB.jpg Immunohistochemistry 1 ARP45599-QC13877-IHC.jpg

 

Protein Accession#	Swissprot Id	Nucleotide Accession#	Protein Size	Molecular Weight
NP_000892	P08235	NM_000901	984	107kDa