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Transcription Factor Antibodies
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> Products >Transcription Factor Antibodies :
Other Transcription Factors
| ATG4B (ATG4 autophagy related 4 homolog B (S. cerevisiae)) Antibody |
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Description:
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. APG4B encodes a member of the autophagin protein family and is also designated as a member of the C-54 family of cysteine proteases.Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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Species Reactivity:
Human,Mouse,Rat,Dog
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Gene Symbol:
ATG4B
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Alias_Symbols:
APG4B, AUTL1, MGC1353
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Peptide ID:
Y00336
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ELISA titre using peptide based assay:
1:12500
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Click Here to view more information (protein size, molecular weight, etc)
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Antigen Specificity:
Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human ATG4B with an internal ID of Y00336
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Reconstitution and Storage:
Antibody is lyophilized from PBS buffer with 2% sucrose. Add 100 µl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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Key Reference:
Kumanomidou,T., (2006) J. Mol. Biol. 355 (4), 612-618
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Quality Control:
Rabbit IgG purified by protein A chromatography.
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| Suggested starting concentrations are provided.
Optimal dilutions should be determined by end-user. Differences in calculated versus apparent
molecular weight may be due to post-translational modifications or protein hydrophobicity. For
research use only not for diagnostic, human, or veterinary use. |
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Western Blot
Suggested dilution at 2.5µg/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as second antibody.
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Immunoblot
ARP34434-QC8990-WB.jpg
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