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Home > Products >  Antibodies
Home > Products >Antibodies :   Signaling Intermediates
Home > Products >Antibodies :   Transcription Regulators
Home > Products >  Transcription Factor Antibodies
Home > Products >Transcription Factor Antibodies :   Nuclear Receptor

NR2C1 (nuclear receptor subfamily 2, group C, member 1) Antibody

Preview
Catalog#   Accession # Size Price Qty
P100812_T100   NP_003288 100µg $198.00
  Description: 
The nuclear orphan receptors NR2C1 represses transcription and binds DNA as a homodimer. NR2C1 binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. NR2C1 may function as a negative modulator to suppress androgen receptor function in prostate cancer. NR2C1 may exert an important repressor in regulating ER activity in mammary glands. The nuclear orphan receptors TR2 (NR2C1) and TR4 form a heterodimer that binds to the epsilon and gamma globin promoter DR1 sites
Species Reactivity: 
Human,Dog  
Gene Symbol: 
NR2C1  
Alias_Symbols: 
TR2, TR2-11  
Peptide ID: 
P01895  
ELISA titre using peptide based assay: 
1:312500  
Click Here to view more information (protein size, molecular weight, etc)
Antigen Specificity: 
Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human NR2C1 with an internal ID of P01895 
Reconstitution and Storage: 
Antibody is lyophilized from PBS buffer with 2% sucrose. Add 100 µl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. 
Key Reference: 
Li,G., et al., (2003) Biochem. Biophys. Res. Commun. 310 (2), 384-390 
Quality Control: 
Rabbit IgG purified by protein A chromatography. 
Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. For research use only not for diagnostic, human, or veterinary use.
Western Blot
Suggested dilution at 2.5µg/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as second antibody.
Immunoblot

P100812-QC8848-WB.jpg
 
Protein_Accession# Protein Size Nucleotide Accession# Swissprot Id Molecular Weight
NP_003288 603 NM_003297 Q15625 67kDa