ESR2(estrogen receptor 2 (ER beta)) Antibody

Preview

Catalog#

Accession #

Size

Price

Qty

ARP32258_P050

NP_001428

50µg

$289.00

Description:
ESR2 is a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. It contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.

Gene Symbol:
ESR2

Alias Symbols:
ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2

Peptide ID:
P03239

ELISA titre using peptide based assay:
1:62500

Search Keyword:
ESR2, ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2, NP_001428

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Species Reactivity:
(Primary - WB; Secondary - Computational Homology)
Human

Antigen Specificity:
Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human ESR2 with an internal ID of P03239

Reconstitution and Storage:
Antibody is lyophilized from PBS buffer with 2% sucrose. Add 50 μl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.

Key Reference:
Onsory,K., Mol. Cell. Biochem. 314 (1-2), 25-35 (2008)

Quality Control:
Rabbit Ig G is purified by peptide affinity chromatography method.

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. For research use only not for diagnostic, human, or veterinary use.

Western Blot
Suggested dilution at 1µg/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as second antibody.

Immunoblot

ARP32258-QC1719-WB.jpg

Protein Accession#	Swissprot Id	Nucleotide Accession#	Protein Size	Molecular Weight
NP_001428	Q92731	NM_001437	530	59kDa