CCBP2 Antibody - N-terminal region (ARP30776_P050)

Catalog No: ARP30776_P050

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WB Suggested Anti-CCBP2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Jurkat cell lysate

Human Muscle

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: IHC, WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CCBP2
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human: 100%; Rabbit: 86%
• Peptide Sequence: Synthetic peptide located within the following region: MAATASPQPLATEDADSENSSFYYYDYLDEVAFMLCRKDAVVSFGKVFLP
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-ACKR2 (ARP30776_P050) antibody is Catalog # AAP30776 (Previous Catalog # AAPP24009)
• Reference: Galliera,E., (2004) J. Biol. Chem. 279 (24), 25590-25597

Target Info

• Gene Symbol: ACKR2
• Gene Full Name: Chemokine binding protein 2
• Alias Symbols: D6, hD6, CCR9, CCBP2, CCR10, CMKBR9
• NCBI Gene Id: 1238
• Protein Name: Chemokine-binding protein 2
• Description of Target: CCBP2 is a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown.This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.
• Uniprot ID: O00590
• Protein Accession #: NP_001287
• Nucleotide Accession #: NM_001296
• Protein Size (# AA): 384
• Molecular Weight: 43kDa
• Protein Interactions: APP; CCL3L3; CCL28; CCL27; CCL21; CCL25; CCL8; CCL19; CCL14; CCL13; CCL11; CCL5; CCL4; CCL3; CCL7; CCL2;