CBFA2T3 Antibody (OAAF02383)

Catalog No: OAAF02383 (Formerly GWB-ASD621)

Size:100 ug

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using MTG16 Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human MTG16.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: MTG16 antibody detects endogenous levels of total MTG16 protein.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: IHC: 1:50~1:100; ELISA: 1:20000
• Reference: Gamou T., Blood 91:4028-4037(1998).
  Calabi F., Genomics 52:332-341(1998).
  Salomon-Nguyen F., Leukemia 14:1704-1705(2000).

Target Info

• Gene Symbol: CBFA2T3
• Gene Full Name: CBFA2/RUNX1 partner transcriptional co-repressor 3
• Alias Symbols: CBFA2/RUNX1 translocation partner 3;core-binding factor, runt domain, alpha subunit 2; translocated to, 3;ETO2;MTG16;MTG8-related gene 2;MTG8-related protein 2;MTGR2;myeloid translocation gene 8 and 16b;myeloid translocation gene on chromosome 16 protein;protein CBFA2T3;RUNX1T3;zinc finger MYND domain-containing protein 4;ZMYND4.
• NCBI Gene Id: 863
• Protein Name: Protein CBFA2T3
• Description of Target: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed:15231665).
• Uniprot ID: O75081|Q0P5Z6
• Protein Accession #: NP_005178.4
• Molecular Weight: 71 kDa