CASP3 Antibody (OAAH00031)

Catalog No: OAAH00031

Size:100 ul

Endogenous Caspase-3 detected in 293T(Lane1), F9(Lane2), NIH3T3(Lane3) cell lysates
Primary antibody: 1:500

Product Info

• Predicted Species Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse IgG
• Host: Mouse
• Application: WB, IF, IHC
• Additional Information: Localization: Cytoplasm
• Reconstitution and Storage: Store the product at -20C. Stable for one year from the date of shipment.
• Immunogen: This Aviva monoclonal antibody is produced by immunizing mice with recombinant polypeptide (Aviva SEAL mAb technology) corresponding to surface multi-epitopes of human Caspase-3.
• Specificity: Caspase-3 Mouse monoclonal antibody detects endogenous levels of Caspase-3 protein.
• Source: Mouse mAb
• Application Info: WB: 1:500-1:1000
• Reference: 1.Benhar, M., Forrester, M. T., Hess, D. T., Science 320: 1050-1054, 2008.
  2.Gervais, F. G., Xu, D., Robertson, G. S., Cell 97: 395-406, 1999.
  3.Lakhani, S. A., Masud, A., Kuida, K., Science 311: 847-851, 2006.
  

Target Info

• Gene Symbol: CASP3
• Gene Full Name: Caspase-3
• Alias Symbols: CPP32, SCA-1, CPP32B
• NCBI Gene Id: 836
• Protein Name: Caspase-3
• Description of Target: This gene is a member of the cysteine-aspartic acid protease (caspase) family. Alternative splicing of this gene results in two transcript variants that encode the same protein. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases-3 exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspases-3 cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10
• Uniprot ID: P42574
• Protein Accession #: NP_004337.2; NP_116786.1
• Nucleotide Accession #: NM_004346.3; NM_032991.2
• Protein Size (# AA): 277
• Molecular Weight: 32 kDa