CALDESMON Antibody (OAAD00124)

Catalog No: OAAD00124

Size:100 ug

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Clonality: Monoclonal
• Clone: CD-7
• Isotype: IgG1
• Host: Mouse
• Application: WB, IHC
• Reconstitution and Storage: At -20C for one year. After reconstitution, at 4C for three month. It can also be aliquotted and stored frozen at -20C for longer time.
• Immunogen: Caldesmon from turkey gizzard
• Purification: Purified by the goat anti-mouse IgG Affinity chromatography.
• Specificity: Human, mouse, rat.
  No cross reactivity with other proteins.
• Formulation: Lyophilized from 1.2% sodium acetate, with 2mg BSA and 0.01mg NaN3 as preservative.
• Application Info: Western blot At 1-2ug/ml with the appropriate system to detect caldesmon (smooth) in cells and tissues.
  Immunohistochemistry(F) At 2-4ug/ml to detect caldesmon (smooth) in formalin fixed and paraffin embedded tissues.
  Other applications have not been tested.
  Optimal dilutions should be determined by end user.
• Storage Buffer: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.
• Reference: 1. Humphrey, M. B.; Herrera-Sosa, H.; Gonzalez, G.; Lee, R.; Bryan, J. : Cloning of cDNAs encoding human caldesmons. Gene 112: 197-204, 1992.
  2. Hayashi, K.; Yano, H.; Hashida, T.; Takeuchi, R.; Takeda, O.; Asada, K.; Takahashi, E.; Kato, I.; Sobue, K. : Genomic structure of the human caldesmon gene. Proc. Nat. Acad. Sci. 89: 12122-12126, 1992.

Target Info

• Gene Symbol: CALD1
• Alias Symbols: CDM, HCAD, LCAD, H-CAD, L-CAD, NAG22
• NCBI Gene Id: 800
• Protein Name: Caldesmon
• Description of Target: Caldesmon is a potential actomyosin regulatory protein found in smooth muscle and nonmuscle cells.
  The predicted smooth-muscle polypeptide is 793 amino acids long. The high molecular weight caldesmon (h-CaD) is predominantly expressed in smooth muscles, whereas the low molecular weight caldesmon (l-CaD) is widely distributed in nonmuscle tissues and cells. Hayashi et al. (1992) demonstrated that the human CDM gene is composed of 14 exons.
• Uniprot ID: Q05682