website statistics
Account Login 

Now Offering Over 85,203 Antibodies & 34,301 Antigens!

US

CAD antibody - C-terminal region (ARP46104_P050)

Scroll Horizontally to view all Images
Click here to learn more about Aviva's By-Request Conjugation Service.
Print Page
100 ul
    $289.00
    In Stock
    Click here to learn more about Aviva's By-Request Conjugation Service.
    Gene Symbol:
    CAD
    NCBI Gene Id:
    790
    Official Gene Full Name:
    Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
    Protein Name:
    CAD protein
    Swissprot Id:
    P27708
    Protein Accession #:
    NP_004332
    Nucleotide Accession #:
    NM_004341
    Alias Symbols:
    -
    Description of Target:
    CAD is a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Protein Size (# AA):
    2225
    Molecular Weight:
    243kDa
    Host:
    Rabbit
    Clonality:
    Polyclonal
    Purification:
    Affinity Purified
    Application:
    WB
    Tissue Tool:
    Find tissues and cell lines supported by DNA array analysis to express CAD.
    RNA Seq:
    Find tissues and cell lines supported by RNA-seq analysis to express CAD.
    Immunogen:
    The immunogen is a synthetic peptide directed towards the C terminal region of human CAD
    Species Reactivity:
    Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish
    Predicted Homology Based on Immunogen Sequence:
    Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 92%; Zebrafish: 100%
    Complete computational species homology data:
    Anti-CAD (ARP46104_P050)
    Peptide Sequence:
    Synthetic peptide located within the following region: ADVVVLRHPQPGAVELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREEL
    Product Format:
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Reconstitution and Storage:
    For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
    Concentration:
    Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
    Protein Interactions:
    UBC; TUBG1; TP53; SUMO2; SPRTN; STAU1; LGR4; SUMO1; NEDD8; WWOX; NEDD4; FBXO6; HDAC6; ILK; CDK2; HDAC11; HTRA2; TP63; NOS2; ITGA4; RUVBL1; XPO1; VARS; TUBB2A; TUBA4A; SMARCC2; SMARCA4; RPS3; PSMD1; PSMC2; RUVBL2; TUBB4B; SHC1; SMAD2; GRB2; CBL; CUL3; FBXO
    Blocking Peptide:
    For anti-CAD (ARP46104_P050) antibody is Catalog # AAP46104 (Previous Catalog # AAPP26966)
    Datasheets / Downloads:
    Printable datasheet for anti-CAD (ARP46104_P050) antibody
    Target Reference:
    Olsen,J.V., (2006) Cell 127 (3), 635-648

    Product Protocols: CAD antibody tested with Human Fetal Lung Tissue (ARP46104_P050)

    Aviva Systems Biology is the original manufacturer of this CAD antibody (ARP46104_P050)

    Click here to view the CAD antibody Western Blot Protocol

    Product Datasheet Link: CAD antibody (ARP46104_P050)

    WB Suggested Anti-CAD Antibody Titration: 0.2-1 ug/ml
    ELISA Titer: 1:312500
    Positive Control: Fetal Lung

    Western Blot image:


    Description of Target: CAD is a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

    Questions pertaining to this data can be directed to techsupport@avivasysbio.com

    Aviva Systems Biology’s CAD antibody (ARP46104_P050) has been tested using other cell lysates and tissues. To obtain more data about this antibody please email us at info@avivasysbio.com.

    To order by phone call us at (888) 880-0001, fax us at (858) 552-6975 or send an email to info@avivasysbio.com. Aviva manufactures this antibody so we can offer the best price. Please contact us to request pricing information.

    All of Aviva’s products are guaranteed for the applications and experimental sample types mentioned in the datasheet below. Are you curious if this product will work for you? Please contact us at techsupport@avivasysbio.com

     
    X
    Ask a Question