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Catalog No: OAAB17416
Size:400ul
Price: $438.00
SKU
OAAB17416
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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Datasheets/ManualsPrintable datasheet for OAAB17416
Product Info
Predicted Species ReactivityHuman
Product FormatPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
ClonalityPolyclonal
IsotypeIg
HostRabbit
ApplicationWB
Additional InformationPrecautions: BUBR1 (BUB1B) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
::Function: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression
::Cellular Location: Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, centrosome. Note=Cytoplasmic in interphase cells. Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and CASC5
Tissue Location: Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index
Reconstitution and StorageMaintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThis BUBR1 (BUB1B) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-33 amino acids from the N-terminal region of human BUBR1 (BUB1B).
Predicted Homology Based on Immunogen SequenceHuman
ConcentrationApproximately 0.5mg/ml. Actual concentration varies with each lot.
Sample Type Confirmation

BUB1B is strongly supported by BioGPS gene expression data to be expressed in HEK293

Application InfoWB: 1:1000
IHC-P: 1:50~100
Gene SymbolBUB1B
Alias SymbolsMVA1, SSK1, BUBR1, Bub1A, MAD3L, hBUBR1, BUB1beta
NCBI Gene Id701
Protein NameMitotic checkpoint serine/threonine-protein kinase BUB1 beta
Description of TargetPurified Rabbit Polyclonal Antibody (Pab)
Uniprot IDO60566
Protein Accession #NP_001202.4
Molecular Weight119545 Da
  1. What is the species homology for "BUBR1 Antibody - N-terminal region (OAAB17416)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "BUBR1 Antibody - N-terminal region (OAAB17416)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "BUBR1 Antibody - N-terminal region (OAAB17416)" provided in?

    This item is provided in "Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "BUBR1 Antibody - N-terminal region (OAAB17416)"?

    This target may also be called "MVA1, SSK1, BUBR1, Bub1A, MAD3L, hBUBR1, BUB1beta" in publications.

  5. What is the shipping cost for "BUBR1 Antibody - N-terminal region (OAAB17416)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "BUBR1 Antibody - N-terminal region (OAAB17416)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "BUBR1 Antibody - N-terminal region (OAAB17416)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "119545 Da".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "BUBR1 Antibody - N-terminal region (OAAB17416)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "BUB1B"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "BUB1B"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "BUB1B"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "BUB1B"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "BUB1B"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "BUB1B"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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