BATF2 Antibody - N-terminal region (ARP47711_P050)

Catalog No: ARP47711_P050

Lane 1: 40 ug
Mouse Macrophages day 0 (untreated)
Lane 2: 40 ug
Mouse Macrophages day 2 (untreated)
Lane 3: 40 ug
Mouse Macrophages (LPS and IFN gamma)
Primary antibody dilution:
1:200
Secondary antibody used :
goat anti-rabbit IgG, HRP conjugate
Secondary antibody dilution:
1:15000
Submitted by:
Marie Gehman, University of Kentucky

Product Info

• Tested Species Reactivity: Mouse
• Predicted Species Reactivity: Human, Yeast
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human BATF2
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human: 100%; Yeast: 77%
• Peptide Sequence: Synthetic peptide located within the following region: CGGNGLLTQTDPKEQQRQLKKQKNRAAAQRSRQKHTDKADALHQQHESLE
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-BATF2 (ARP47711_P050) antibody is Catalog # AAP47711

Target Info

• Gene Symbol: BATF2
• Gene Full Name: basic leucine zipper transcription factor, ATF-like 2
• Alias Symbols: SARI
• NCBI Gene Id: 116071
• Protein Name: Basic leucine zipper transcriptional factor ATF-like 2
• Description of Target: BATF2 is a AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, it participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. It acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). It selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. It possibly acts by interfering with AP-1 binding to CYR61 promoter.
• Uniprot ID: Q8N1L9
• Protein Size (# AA): 274
• Molecular Weight: 30kDa
• Protein Interactions: DAZAP2; MAFF; JUNB; JUN; EPAS1; DDIT3; DBP; CEBPG; CEBPE; CEBPA; ATF4; C2orf88; DEDD; RELA; HLA-C; KAT2A; ATXN1;