BAK1 Antibody (OAPA00354)

Catalog No: OAPA00354 (Formerly GWB-BSP883)

Size:5UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: 1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
• Clonality: Monoclonal
• Clone: PAT8B4AT
• Isotype: Mouse IgG2a heavy chain and k light chain.
• Host: Mouse
• Application: IF, WB
  Product Introduction: BAK1 is a member of the BCL2 protein family. The BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators which are involved in a wide variety of cellular activities. The BAK1 gene encodes a receptor-like kinase (RLK) with a putative extracellular domain, a single transmembrane domain, an intracellular-juxtamembrane domain, and a kinase domain. BAK1 localizes to mitochondria, and functions to induce apoptosis. BAK1 interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, leading to a loss in membrane potential and the release of cytochrome c. Furthermore, BAK1 interacts with the tumor suppressor P53 after exposure to cell stress. BAK1 expression is linked to the progression of Prostate cancer.
• Reconstitution and Storage: For periods up to 1 month store at 4C, for longer periods of time, store at -20C. Prevent freeze thaw cycles.
  Stability: 12 months at -20C. 1 month at 4C.
• Immunogen: The immunogen for anti-BAK1 antibody: anti-human BAK1 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human BAK1 amino acids 29-187 purified from E. coli.
• Predicted Homology Based on Immunogen Sequence: Human
• Purity: BAK1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
• Application Info: BAK1 antibody has been tested by ELISA, Western blot and Immunofluorescence analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis and Immunofluorescence is 1:250 ~ 500. Recommended starting dilution is 1:250.

Target Info

• Gene Symbol: BAK1
• Alias Symbols: BAK, CDN1, BCL2L7, BAK-LIKE
• NCBI Gene Id: 578
• Protein Name: Bcl-2 homologous antagonist/killer
• Description of Target: Mouse Anti Human Bcl-2 homologous antagonist/killer
• Uniprot ID: Q16611