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No.GeneCatalog NumberPublicationPubmed Link
1 ABCC4 OAEB02455 Gori, I. et al. Augmented epithelial multidrug resistance-associated protein 4 expression in peritoneal endometriosis: regulation by lipoxin A(4). Fertil. Steril. 99, 1965–73.e2 (2013). 23472950
2 ABCC4 OAEB02455 Montani, M. et al. Multidrug resistance protein 4 (MRP4) expression in prostate cancer is associated with androgen signaling and decreases with tumor progression. Virchows Arch. 462, 437–43 (2013). 23503867
3 ALB ARP41746_P050 Holzer, M. et al. Uremia alters HDL composition and function. J. Am. Soc. Nephrol. 22, 1631–41 (2011). 21804091
4 ANXA3 ARP36578_T100 Bianchi, C. et al. Primary cell cultures from human renal cortex and renal-cell carcinoma evidence a differential expression of two spliced isoforms of Annexin A3. Am. J. Pathol. 176, 1660–70 (2010). 20167856
5 ANXA3 ARP36578_T100 Seliger, B. et al. Combined analysis of transcriptome and proteome data as a tool for the identification of candidate biomarkers in renal cell carcinoma. Proteomics 9, 1567–81 (2009). 19235166
6 ANXA4 ARP36686_T100 de la Cuesta, F. et al. A proteomic focus on the alterations occurring at the human atherosclerotic coronary intima. Mol. Cell. Proteomics 10, M110.003517 (2011). 21248247
7 ANXA4 ARP36686_T100 Staquicini, F. I. et al. Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients. Proc. Natl. Acad. Sci. U. S. A. 108, 18637–42 (2011). 22049339
8 ARG2 ARP54567_P050 Lukasova, M., Malaval, C., Gille, A., Kero, J. & Offermanns, S. Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells. J. Clin. Invest. 121, 1163–73 (2011). 21317532
9 ARL13B ARP52779_P050 Zhang, Z. et al. Fuz regulates craniofacial development through tissue specific responses to signaling factors. PLoS One 6, e24608 (2011). 21935430
10 BMP7 ARP32329_T100 Whiteland, H. et al. Putative prognostic epithelial-to-mesenchymal transition biomarkers for aggressive prostate cancer. Exp. Mol. Pathol. 95, 220–6 (2013). 23933194
11 BMP7 ARP32329_T100 Lovric, V. et al. Effects of demineralized bone matrix on tendon-bone healing in an intra-articular rodent model. Am. J. Sports Med. 40, 2365–74 (2012). 22984131
12 BMP7 ARP32329_T100 Fiaschetti, G. et al. Bone morphogenetic protein-7 is a MYC target with prosurvival functions in childhood medulloblastoma. Oncogene 30, 2823–35 (2011). 21317922
13 BMP7 ARP32329_T100 Filion, T. M. et al. Elastomeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats. Tissue Eng. Part A 17, 503–11 (2011). 20818999
14 BMP7 ARP32329_T100 Rui, Y. F. et al. Expression of chondro-osteogenic BMPs in clinical samples of patellar tendinopathy. Knee Surg. Sports Traumatol. Arthrosc. 20, 1409–17 (2012). 21946950
15 BMP7 ARP32329_T100 Mae, S.-I. et al. Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells. Biochem. Biophys. Res. Commun. 393, 877–82 (2010). 20171952
16 BMP7 ARP32329_T100 Yi, T. et al. Regulation of embryonic kidney branching morphogenesis and glomerular development by KISS1 receptor (Gpr54) through NFAT2- and Sp1-mediated Bmp7 expression. J. Biol. Chem. 285, 17811–20 (2010). 20375015
17 BMP7 ARP32329_T100 Morrissey, C., Brown, L. G., Pitts, T. E. M., Vessella, R. L. & Corey, E. Bone morphogenetic protein 7 is expressed in prostate cancer metastases and its effects on prostate tumor cells depend on cell phenotype and the tumor microenvironment. Neoplasia 12, 192–205 (2010). 20126477
18 BMP7 ARP32329_T100 Lovric, V. et al. Effects of demineralized bone matrix on tendon-bone healing in an intra-articular rodent model. Am. J. Sports Med. 40, 2365–74 (2012). 22984131
19 BMP7 ARP32329_T100 Fiaschetti, G. et al. Bone morphogenetic protein-7 is a MYC target with prosurvival functions in childhood medulloblastoma. Oncogene 30, 2823–35 (2011). 21317922
20 BMP7 ARP32329_T100 Filion, T. M. et al. Elastomeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats. Tissue Eng. Part A 17, 503–11 (2011). 20818999
21 BMP7 ARP32329_T100 Rui, Y. F. et al. Expression of chondro-osteogenic BMPs in clinical samples of patellar tendinopathy. Knee Surg. Sports Traumatol. Arthrosc. 20, 1409–17 (2012). 21946950
22 BMP7 ARP32329_T100 Mae, S.-I. et al. Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells. Biochem. Biophys. Res. Commun. 393, 877–82 (2010). 20171952
23 BMP7 ARP32329_T100 Yi, T. et al. Regulation of embryonic kidney branching morphogenesis and glomerular development by KISS1 receptor (Gpr54) through NFAT2- and Sp1-mediated Bmp7 expression. J. Biol. Chem. 285, 17811–20 (2010). 20375015
24 BMP7 ARP32329_T100 Morrissey, C., Brown, L. G., Pitts, T. E. M., Vessella, R. L. & Corey, E. Bone morphogenetic protein 7 is expressed in prostate cancer metastases and its effects on prostate tumor cells depend on cell phenotype and the tumor microenvironment. Neoplasia 12, 192–205 (2010). 20126477
25 BRCA1 AVARP02017_P050 Kim, J.-H., Yu, C.-H., Yhee, J.-Y., Im, K.-S. & Sur, J.-H. Lymphocyte infiltration, expression of interleukin (IL) -1, IL-6 and expression of mutated breast cancer susceptibility gene-1 correlate with malignancy of canine mammary tumours. J. Comp. Pathol. 142, 177–86 19959182
26 CAV2 AVARP09020_P050 Chi Sabins, N. et al. DLK1: a novel target for immunotherapeutic remodeling of the tumor blood vasculature. Mol. Ther. 21, 1958–68 (2013). 23896726
27 CKAP4 ARP46790_P050 Clark, R. et al. Comparative genomic and proteomic analysis of cytoskeletal changes in dexamethasone-treated trabecular meshwork cells. Mol. Cell. Proteomics 12, 194–206 (2013). 23105009
28 COX4I1 ARP42784_T100 Snyder, A. M. et al. Mitochondrial ferritin in the substantia nigra in restless legs syndrome. J. Neuropathol. Exp. Neurol. 68, 1193–9 (2009). 19816198
29 CYP3A4 ARP51349_P050 Werk, A. N. et al. Identification and Characterization of a Defective CYP3A4 Genotype in a Kidney Transplant Patient With Severely Diminished Tacrolimus Clearance. Clin. Pharmacol. Ther. 95, 416–22 (2014). 24126681
30 DAZAP1 ARP41161_P050 Hayakawa, H. et al. Human proteins that specifically bind to 8-oxoguanine-containing RNA and their responses to oxidative stress. Biochem. Biophys. Res. Commun. 403, 220–4 (2010). 21073862
31 DGCR8 ARP40984_P050 Van Duyne, R. et al. Localization and sub-cellular shuttling of HTLV-1 tax with the miRNA machinery. PLoS One 7, e40662 (2012). 22808228
32 DGCR8 ARP40984_P050 Kye, M. J. et al. NMDA mediated contextual conditioning changes miRNA expression. PLoS One 6, e24682 (2011). 21931811
33 DLL1 ARP46625_P050 Caliceti, C. et al. 17β-estradiol enhances signalling mediated by VEGF-A-delta-like ligand 4-notch1 axis in human endothelial cells. PLoS One 8, e71440 (2013). 23967210
34 DLL1 ARP46625_P050 Suprynowicz, F. A. et al. Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells. Proc. Natl. Acad. Sci. U. S. A. 109, 20035–40 (2012). 23169653
35 DSG2 ARP45198_P050 Hummitzsch, K. et al. A new model of development of the mammalian ovary and follicles. PLoS One 8, e55578 (2013). 23409002
36 E2F3 ARP38089_P050 Giangreco, A. A. et al. Tumor suppressor microRNAs, miR-100 and -125b, are regulated by 1,25-dihydroxyvitamin D in primary prostate cells and in patient tissue. Cancer Prev. Res. (Phila). 6, 483–94 (2013). 23503652
37 E2F3 ARP38089_P050 Melcher, R. et al. LOH and copy neutral LOH (cnLOH) act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability. Carcinogenesis 32, 636–42 (2011). 21297112
38 E2F3 ARP38089_P050 Naga Prasad, S. V et al. Unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks. J. Biol. Chem. 284, 27487–99 (2009). 19641226
39 EIF2A ARP41041_T100 Xu, Y.-X., Liu, L., Caffaro, C. E. & Hirschberg, C. B. Inhibition of Golgi apparatus glycosylation causes endoplasmic reticulum stress and decreased protein synthesis. J. Biol. Chem. 285, 24600–8 (2010). 20529871
40 EIF3M ARP48293_T100 Cheshenko, N., Trepanier, J. B., Segarra, T. J., Fuller, A. O. & Herold, B. C. HSV usurps eukaryotic initiation factor 3 subunit M for viral protein translation: novel prevention target. PLoS One 5, e11829 (2010). 20676407
41 ENO1 ARP34377_P050 Deng, M. Y. et al. Frontal-subcortical protein expression following prenatal exposure to maternal inflammation. PLoS One 6, e16638 (2011). 21347362
42 ENO1 ARP34377_P050 Sørensen, B. S. et al. Proteins upregulated by mild and severe hypoxia in squamous cell carcinomas in vitro identified by proteomics. Radiother. Oncol. 92, 443–9 (2009). 19541378
43 ENO1 ARP34377_P050 Boraldi, F. et al. Hypoxia influences the cellular cross-talk of human dermal fibroblasts. A proteomic approach. Biochim. Biophys. Acta 1774, 1402–13 (2007). 17904921
44 FABP3 ARP33823_T100 Chen, H.-M., Zheng, C.-X., Gao, Q., Ge, Y.-C. & Liu, Z.-H. Heart-type fatty acid binding protein is associated with proteinuria in obesity. PLoS One 7, e45691 (2012). 23029183
45 FZD10 ARP41262_P050 Gonzalez, P., Fernandez-Martos, C. M., Gonzalez-Fernandez, C., Arenas, E. & Rodriguez, F. J. Spatio-temporal expression pattern of frizzled receptors after contusive spinal cord injury in adult rats. PLoS One 7, e50793 (2012). 23251385
46 FZD4 ARP41266_P050 Wang, L. et al. Impact of laminitis on the canonical Wnt signaling pathway in basal epithelial cells of the equine digital laminae. PLoS One 8, e56025 (2013). 23405249
47 FZD4 ARP41266_P050 McIver, S. C. et al. A unique combination of male germ cell miRNAs coordinates gonocyte differentiation. PLoS One 7, e35553 (2012). 22536405
48 FZD4 ARP41266_P050 Gonzalez, P., Fernandez-Martos, C. M., Gonzalez-Fernandez, C., Arenas, E. & Rodriguez, F. J. Spatio-temporal expression pattern of frizzled receptors after contusive spinal cord injury in adult rats. PLoS One 7, e50793 (2012). 23251385
49 FZD7 ARP41251_P050 McIver, S. C. et al. A unique combination of male germ cell miRNAs coordinates gonocyte differentiation. PLoS One 7, e35553 (2012). 22536405
50 FZD7 ARP41251_P050 Gökmen-Polar, Y. et al. Dual targeting of EphA2 and ER restores tamoxifen sensitivity in ER/EphA2-positive breast cancer. Breast Cancer Res. Treat. 127, 375–84 (2011). 20602165
51 FZD7 ARP41251_P050 Ohba, S., Lanigan, T. M. & Roessler, B. J. Leptin receptor JAK2/STAT3 signaling modulates expression of Frizzled receptors in articular chondrocytes. Osteoarthritis Cartilage 18, 1620–9 (2010). 20868760
52 GABRE ARP35342_P050 Fatemi, S. H., Folsom, T. D., Rooney, R. J. & Thuras, P. D. Expression of GABAA α2-, β1- and ε-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder. Transl. Psychiatry 3, e303 (2013). 24022508
53 GABRE ARP35342_P050 Hengen, K. B. et al. Increased GABA(A) receptor ε-subunit expression on ventral respiratory column neurons protects breathing during pregnancy. PLoS One 7, e30608 (2012). 22303446
54 GABRE ARP35342_P050 Hengen, K. B., Gomez, T. M., Stang, K. M., Johnson, S. M. & Behan, M. Changes in ventral respiratory column GABAaR ε- and δ-subunits during hibernation mediate resistance to depression by EtOH and pentobarbital. Am. J. Physiol. Regul. Integr. Comp. Physiol. 300, R272–83 (2011). 21084677
55 GATA2 ARP31855_T100 Wang, F. et al. A regulatory circuit comprising GATA1/2 switch and microRNA-27a/24 promotes erythropoiesis. Nucleic Acids Res. 42, 442–57 (2014). 24049083
56 GATA2 ARP31855_T100 Fujiwara, T. et al. Gene expression profiling identifies HOXB4 as a direct downstream target of GATA-2 in human CD34+ hematopoietic cells. PLoS One 7, e40959 (2012). 23028422
57 GATA2 ARP31855_T100 Jack, B. H. A. & Crossley, M. GATA proteins work together with friend of GATA (FOG) and C-terminal binding protein (CTBP) co-regulators to control adipogenesis. J. Biol. Chem. 285, 32405–14 (2010). 20705609
58 GATA2 ARP31855_T100 Huang, Y.-J. et al. The functional IGFBP7 promoter -418G>A polymorphism and risk of head and neck cancer. Mutat. Res. 702, 32–9 (2010). 20599521
59 GATA2 ARP31855_T100 Mammoto, A. et al. A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature 457, 1103–8 (2009). 19242469
60 GLI2 ARP31885_T100 Bosco-Clément, G. et al. Targeting Gli transcription activation by small molecule suppresses tumor growth. Oncogene 33, 2087–97 (2014). 23686308
61 GLI2 ARP31885_T100 Li, Y. et al. Gene expression profiling reveals the heterogeneous transcriptional activity of Oct3/4 and its possible interaction with Gli2 in mouse embryonic stem cells. Genomics 102, 456–67 24121003
62 GLI2 ARP31885_T100 Yang, L. et al. Hedgehog signaling activation in the development of squamous cell carcinoma and adenocarcinoma of esophagus. Int. J. Biochem. Mol. Biol. 3, 46–57 (2012). 22509480
63 GLI2 ARP31885_T100 Malek, R., Matta, J., Taylor, N., Perry, M. E. & Mendrysa, S. M. The p53 inhibitor MDM2 facilitates Sonic Hedgehog-mediated tumorigenesis and influences cerebellar foliation. PLoS One 6, e17884 (2011). 21437245
64 GLI2 ARP31885_T100 Jung, I. H., Jung, D. E., Park, Y. N., Song, S. Y. & Park, S. W. Aberrant Hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish. PLoS One 6, e27941 (2011). 22164219
65 GLI2 ARP31885_T100 Nakamura, K. et al. Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells. PLoS One 5, e8824 (2010). 20098680
66 GLI2 ARP31885_T100 Youssef, K. K. et al. Identification of the cell lineage at the origin of basal cell carcinoma. Nat. Cell Biol. 12, 299–305 (2010). 20154679
67 GLI2 ARP31885_T100 Peacock, Z. S., Cox, D. & Schmidt, B. L. Involvement of PTCH1 mutations in the calcifying epithelial odontogenic tumor. Oral Oncol. 46, 387–92 (2010). 20371205
68 GLI2 ARP31885_T100 Coon, V. et al. Molecular therapy targeting Sonic hedgehog and hepatocyte growth factor signaling in a mouse model of medulloblastoma. Mol. Cancer Ther. 9, 2627–36 (2010). 20807782
69 GLI2 ARP31885_T100 Wall, D. S. et al. Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. J. Cell Biol. 184, 101–12 (2009). 19124651
70 GLI2 ARP31885_T100 Madison, B. B., McKenna, L. B., Dolson, D., Epstein, D. J. & Kaestner, K. H. FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine. J. Biol. Chem. 284, 5936–44 (2009). 19049965
71 GLI2 ARP31885_T100 Takanaga, H. et al. Gli2 is a novel regulator of sox2 expression in telencephalic neuroepithelial cells. Stem Cells 27, 165–74 (2009). 18927476
72 GLI2 ARP31885_T100 Kim, J. E. et al. Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-cell lymphoma. Mod. Pathol. 22, 1312–20 (2009). 19593328
73 GLI2 ARP31885_T100 Kim, W.-Y. et al. GSK-3 is a master regulator of neural progenitor homeostasis. Nat. Neurosci. 12, 1390–7 (2009). 19801986
74 GLI2 ARP31885_T100 Syn, W.-K. et al. Role for hedgehog pathway in regulating growth and function of invariant NKT cells. Eur. J. Immunol. 39, 1879–92 (2009). 19544307
75 GLI2 ARP31885_T100 Ho, L. et al. Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors. Cancer Cell 16, 126–36 (2009). 19647223
76 GLI2 ARP31885_T100 Kabasawa, Y. et al. Amelogenin positive cells scattered in the interstitial component of odontogenic fibromas. J. Clin. Pathol. 61, 851–5 (2008). 18344235
77 GLI2 ARP31885_T100 Omenetti, A. et al. Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J. Clin. Invest. 118, 3331–42 (2008). 18802480
78 GLI2 ARP31885_T100 Omenetti, A. et al. The hedgehog pathway regulates remodelling responses to biliary obstruction in rats. Gut 57, 1275–82 (2008). 18375471
79 GLI2 ARP31885_T100 Kim, Y. et al. Selective down-regulation of glioma-associated oncogene 2 inhibits the proliferation of hepatocellular carcinoma cells. Cancer Res. 67, 3583–93 (2007). 17440069
80 GNAS ARP42693_P050 Moreno-Smith, M. et al. Biologic effects of dopamine on tumor vasculature in ovarian carcinoma. Neoplasia 15, 502–10 (2013). 23633922
81 GNAS ARP42693_P050 Masyuk, A. I. et al. Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling. Am. J. Physiol. Gastrointest. Liver Physiol. 304, G1013–24 (2013). 23578785
82 GTPBP9 ARP40744_P050 Zhang, J., Rubio, V., Lieberman, M. W. & Shi, Z.-Z. OLA1, an Obg-like ATPase, suppresses antioxidant response via nontranscriptional mechanisms. Proc. Natl. Acad. Sci. U. S. A. 106, 15356–61 (2009). 19706404
83 HDAC9 ARP42788_T100 Spallotta, F. et al. Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia. J. Biol. Chem. 288, 22915–29 (2013). 23836913
84 HDAC9 ARP42788_T100 Milde, T. et al. HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth. Clin. Cancer Res. 16, 3240–52 (2010). 20413433
85 HDAC9 ARP42788_T100 Hang, C. T. et al. Chromatin regulation by Brg1 underlies heart muscle development and disease. Nature 466, 62–7 (2010). 20596014
86 HEYL ARP31866_T100 Morrow, D. et al. Sonic Hedgehog induces Notch target gene expression in vascular smooth muscle cells via VEGF-A. Arterioscler. Thromb. Vasc. Biol. 29, 1112–8 (2009). 19407245
87 HGF ARP44317_P050 Nejak-Bowen, K., Orr, A., Bowen, W. C. & Michalopoulos, G. K. Conditional genetic elimination of hepatocyte growth factor in mice compromises liver regeneration after partial hepatectomy. PLoS One 8, e59836 (2013). 23527275
88 HGF ARP44317_P050 Zampell, J. C. et al. Lymphatic function is regulated by a coordinated expression of lymphangiogenic and anti-lymphangiogenic cytokines. Am. J. Physiol. Cell Physiol. 302, C392–404 (2012). 21940662
89 HGF ARP44317_P050 Sen, B., Peng, S., Saigal, B., Williams, M. D. & Johnson, F. M. Distinct interactions between c-Src and c-Met in mediating resistance to c-Src inhibition in head and neck cancer. Clin. Cancer Res. 17, 514–24 (2011). 21106725
90 HGF ARP44317_P050 Williams, C. M. et al. Autocrine-controlled formation and function of tissue-like aggregates by primary hepatocytes in micropatterned hydrogel arrays. Tissue Eng. Part A 17, 1055–68 (2011). 21121876
91 HNRPA3 ARP41195_T100 Papadopoulou, C., Patrinou-Georgoula, M. & Guialis, A. Extensive association of HuR with hnRNP proteins within immunoselected hnRNP and mRNP complexes. Biochim. Biophys. Acta 1804, 692–703 (2010). 19931428
92 HNRPA3 ARP41195_T100 Süss, C. et al. Rapid changes of mRNA-binding protein levels following glucose and 3-isobutyl-1-methylxanthine stimulation of insulinoma INS-1 cells. Mol. Cell. Proteomics 8, 393–408 (2009). 18854578
93 HNRPF ARP40565_T100 White, R. et al. Heterogeneous nuclear ribonucleoprotein (hnRNP) F is a novel component of oligodendroglial RNA transport granules contributing to regulation of myelin basic protein (MBP) synthesis. J. Biol. Chem. 287, 1742–54 (2012). 22128153
94 HSD11B1 ARP45714_P050 Kuroda, K. et al. Induction of 11β-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells. Mol. Endocrinol. 27, 192–202 (2013). 23275455
95 HSD11B1 ARP45714_P050 Lei, K. et al. Progesterone acts via the nuclear glucocorticoid receptor to suppress IL-1β-induced COX-2 expression in human term myometrial cells. PLoS One 7, e50167 (2012). 23209664
96 HSD17B6 ARP41529_T100 Mohler, J. L. et al. Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer. Cancer Res. 71, 1486–96 (2011). 21303972
97 HSD17B6 ARP41529_T100 Muthusamy, S. et al. Estrogen receptor β and 17β-hydroxysteroid dehydrogenase type 6, a growth regulatory pathway that is lost in prostate cancer. Proc. Natl. Acad. Sci. U. S. A. 108, 20090–4 (2011). 22114194
98 ID4 ARP38058_T100 Melcher, R. et al. LOH and copy neutral LOH (cnLOH) act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability. Carcinogenesis 32, 636–42 (2011). 21297112
99 IGFBP4 ARP45685_P050 Shi, Z., Chiang, C.-I., Mistretta, T.-A., Major, A. & Mori-Akiyama, Y. SOX9 directly regulates IGFBP-4 in the intestinal epithelium. Am. J. Physiol. Gastrointest. Liver Physiol. 305, G74–83 (2013). 23660500
100 ISGF3G ARP31200_P050 Bidwell, B. N. et al. Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape. Nat. Med. 18, 1224–31 (2012). 22820642
101 KCNN2 ARP35094_T100 Chakroborty, S. et al. Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer’s disease mice. J. Neurosci. 32, 8341–53 (2012). 22699914
102 KCNN2 ARP35439_P050 Chakroborty, S. et al. Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer’s disease mice. J. Neurosci. 32, 8341–53 (2012). 22699914
103 KIF5B ARP33903_P050 Turner, L. S. et al. Autophagy is increased in prostate cancer cells overexpressing acid ceramidase and enhances resistance to C6 ceramide. Prostate Cancer Prostatic Dis. 14, 30–7 (2011). 21116286
104 LRRC50 ARP53359_P050 Basten, S. G. et al. Mutations in LRRC50 predispose zebrafish and humans to seminomas. PLoS Genet. 9, e1003384 (2013). 23599692
105 MAZ ARP38146_P050 Smits, M. et al. Myc-associated zinc finger protein (MAZ) is regulated by miR-125b and mediates VEGF-induced angiogenesis in glioblastoma. FASEB J. 26, 2639–47 (2012). 22415301
106 MEIS2 ARP34684_T100 Jackson, B. et al. TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier. J. Cell Sci. 124, 1681–90 (2011). 21511732
107 MRPS15 ARP33299_P050 Davies, S. M. K. et al. Pentatricopeptide repeat domain protein 3 associates with the mitochondrial small ribosomal subunit and regulates translation. FEBS Lett. 583, 1853–8 (2009). 19427859
108 MUC3B ARP58395_P050 Song, J. S. et al. Comparative gene expression analysis of the human periodontal ligament in deciduous and permanent teeth. PLoS One 8, e61231 (2013). 23593441
109 Nkx1-2 ARP36974_P050 Buniello, A. et al. Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness. PLoS One 8, e56274 (2013). 23457544
110 NPM1 ARP34094_T100 Komorek, J. et al. Adenovirus type 5 E1A and E6 proteins of low-risk cutaneous beta-human papillomaviruses suppress cell transformation through interaction with FOXK1/K2 transcription factors. J. Virol. 84, 2719–31 (2010). 20053746
111 NR1I2 ARP36016_P050 Sivertsson, L., Edebert, I., Palmertz, M. P., Ingelman-Sundberg, M. & Neve, E. P. A. Induced CYP3A4 expression in confluent Huh7 hepatoma cells as a result of decreased cell proliferation and subsequent pregnane X receptor activation. Mol. Pharmacol. 83, 659–70 (2013). 23264496
112 NR1I2 ARP36016_P050 Dou, W. et al. Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-κB signaling pathway. J. Pharmacol. Exp. Ther. 345, 473–82 (2013). 23536316
113 NR2F2 P100816_P050 Déjardin, J. & Kingston, R. E. Purification of proteins associated with specific genomic Loci. Cell 136, 175–86 (2009). 19135898
114 OAS1 ARP30587_P050 Li, Q. & Tainsky, M. A. Higher miRNA tolerance in immortal Li-Fraumeni fibroblasts with abrogated interferon signaling pathway. Cancer Res. 71, 255–65 (2011). 21199806
115 OAS1 ARP51359_P050 Zhu, W. et al. RIG-I-like receptors mediate innate antiviral response in mouse testis. Mol. Endocrinol. 27, 1455–67 (2013). 23820901
116 OAS1 ARP51359_P050 Yu, L. et al. Pattern recognition receptor-initiated innate antiviral response in mouse adipose cells. Immunol. Cell Biol. 92, 105–15 (2014). 24165978
117 ONECUT1 ARP38481_P050 Yuan, X.-W. et al. Hepatocyte nuclear factor 6 suppresses the migration and invasive growth of lung cancer cells through p53 and the inhibition of epithelial-mesenchymal transition. J. Biol. Chem. 288, 31206–16 (2013). 24022481
118 PAX2 ARP31220_P050 Palmieri, C. et al. Expression of steroid receptor coactivator 3 in ovarian epithelial cancer is a poor prognostic factor and a marker for platinum resistance. Br. J. Cancer 108, 2039–44 (2013). 23652306
119 PAX2 ARP31220_P050 Viringipurampeer, I. A. et al. Pax2 regulates a fadd-dependent molecular switch that drives tissue fusion during eye development. Hum. Mol. Genet. 21, 2357–69 (2012). 22357656
120 PAX2 ARP31220_P050 Lee, S. B. et al. PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cells. PLoS One 6, e22312 (2011). 21876729
121 PAX2 ARP31220_P050 Yu, A. L. et al. Reactivation of optic nerve head astrocytes by TGF-beta2 and H2O2 is accompanied by increased Hsp32 and Hsp47 expression. Invest. Ophthalmol. Vis. Sci. 50, 1707–17 (2009). 18952926
122 PAX2 ARP31220_P050 Hurtado, A. et al. Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen. Nature 456, 663–6 (2008). 19005469
123 PAX2 ARP31220_P050 Yu, A. L. et al. Hypoxia/reoxygenation and TGF-beta increase alphaB-crystallin expression in human optic nerve head astrocytes. Exp. Eye Res. 84, 694–706 (2007). 17261280
124 PAX4 ARP32064_P050 Zhang, L. et al. KIT is an independent prognostic marker for pancreatic endocrine tumors: a finding derived from analysis of islet cell differentiation markers. Am. J. Surg. Pathol. 33, 1562–9 (2009). 19574886
125 PPAP2A ARP42721_T100 Evseenko, D. et al. Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment. PLoS One 8, e63718 (2013). 23696850
126 PRKRA ARP40475_P050 Yoshida, K. et al. Interaction between PKR and PACT mediated by LPS-inducible NF-κB in human gingival cells. J. Cell. Biochem. 113, 165–73 (2012). 21882225
127 RAB35 ARP52267_P050 Kley, R. A. et al. A combined laser microdissection and mass spectrometry approach reveals new disease relevant proteins accumulating in aggregates of filaminopathy patients. Mol. Cell. Proteomics 12, 215–27 (2013). 23115302
128 RCOR1 ARP39178_T100 Packer, A. N., Xing, Y., Harper, S. Q., Jones, L. & Davidson, B. L. The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington’s disease. J. Neurosci. 28, 14341–6 (2008). 19118166
129 SAC ARP47447_P050 Corredor, R. G. et al. Soluble adenylyl cyclase activity is necessary for retinal ganglion cell survival and axon growth. J. Neurosci. 32, 7734–44 (2012). 22649251
130 SFRS10 ARP40528_T100 Fu, K. et al. Tra2β protein is required for tissue-specific splicing of a smooth muscle myosin phosphatase targeting subunit alternative exon. J. Biol. Chem. 287, 16575–85 (2012). 22437831
131 SLC19A1 ARP44167_T100 Halwachs, S., Lakoma, C., Schäfer, I., Seibel, P. & Honscha, W. The antiepileptic drugs phenobarbital and carbamazepine reduce transport of methotrexate in rat choroid plexus by down-regulation of the reduced folate carrier. Mol. Pharmacol. 80, 621–9 (2011). 21737571
132 SLC19A1 ARP44167_T100 Marchi, E. et al. Pralatrexate is synergistic with the proteasome inhibitor bortezomib in in vitro and in vivo models of T-cell lymphoid malignancies. Clin. Cancer Res. 16, 3648–58 (2010). 20501616
133 SLC39A6 ARP43931_T100 Trokovic, N. et al. Exosomal secretion of death bullets: a new way of apoptotic escape? Am. J. Physiol. Endocrinol. Metab. 303, E1015–24 (2012). 22912365
134 SLC5A5 ARP43752_P050 Liu, F. et al. Real-time monitoring of tumorigenesis, dissemination, & drug response in a preclinical model of lymphangioleiomyomatosis/tuberous sclerosis complex. PLoS One 7, e38589 (2012). 22719903
135 SOX5 ARP33323_P050 Fernandes, A. M. et al. Similar properties of chondrocytes from osteoarthritis joints and mesenchymal stem cells from healthy donors for tissue engineering of articular cartilage. PLoS One 8, e62994 (2013). 23671648
136 SOX5 ARP33323_P050 Boije, H. et al. Sonic Hedgehog-signalling patterns the developing chicken comb as revealed by exploration of the pea-comb mutation. PLoS One 7, e50890 (2012). 23227218
137 SOX5 ARP33323_P050 Yu, J. et al. Array-based comparative genomic hybridization identifies CDK4 and FOXM1 alterations as independent predictors of survival in malignant peripheral nerve sheath tumor. Clin. Cancer Res. 17, 1924–34 (2011). 21325289
138 SOX5 ARP33323_P050 Aza-Carmona, M. et al. SHOX interacts with the chondrogenic transcription factors SOX5 and SOX6 to activate the aggrecan enhancer. Hum. Mol. Genet. 20, 1547–59 (2011). 21262861
139 SOX5 ARP33323_P050 Pytel, P. et al. Neoplasms with schwannian differentiation express transcription factors known to regulate normal schwann cell development. Int. J. Surg. Pathol. 18, 449–57 (2010). 20034979
140 SOX5 ARP33323_P050 Wright, D. et al. Copy number variation in intron 1 of SOX5 causes the Pea-comb phenotype in chickens. PLoS Genet. 5, e1000512 (2009). 19521496
141 SOX5 ARP33323_P050 Tchougounova, E. et al. Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence. Oncogene 28, 1537–48 (2009). 19219070
142 SOX5 ARP33323_P050 Martelli, M. L. et al. Exploiting orthologue diversity for systematic detection of gain-of-function phenotypes. BMC Genomics 9, 254 (2008). 18510758
143 SUV420H1 ARP34567_P050 Murata, T. et al. Epigenetic histone modification of Epstein-Barr virus BZLF1 promoter during latency and reactivation in Raji cells. J. Virol. 86, 4752–61 (2012). 22357272
144 SUV420H1 ARP34567_P050 Gatta, R. & Mantovani, R. NF-Y substitutes H2A-H2B on active cell-cycle promoters: recruitment of CoREST-KDM1 and fine-tuning of H3 methylations. Nucleic Acids Res. 36, 6592–607 (2008). 18940868
145 TARDBP ARP38941_T100 Estes, P. S. et al. Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS. Hum. Mol. Genet. 20, 2308–21 (2011). 21441568
146 THRA ARP34780_P050 Kiss-Toth, E., Harlock, E., Lath, D., Quertermous, T. & Wilkinson, J. M. A TNF variant that associates with susceptibility to musculoskeletal disease modulates thyroid hormone receptor binding to control promoter activation. PLoS One 8, e76034 (2013). 24069456
147 VDAC1 ARP35122_T100 Rousset, F., Nguyen, M. V. C., Grange, L., Morel, F. & Lardy, B. Heme oxygenase-1 regulates matrix metalloproteinase MMP-1 secretion and chondrocyte cell death via Nox4 NADPH oxidase activity in chondrocytes. PLoS One 8, e66478 (2013). 23840483
148 VDAC1 ARP35122_T100 Arduíno, D. M. et al. Mitochondrial metabolism in Parkinson’s disease impairs quality control autophagy by hampering microtubule-dependent traffic. Hum. Mol. Genet. 21, 4680–702 (2012). 22843496
149 VDAC1 ARP35122_T100 Chen, S. et al. Reduced expression of lamin A/C results in modified cell signaling and metabolism coupled with changes in expression of structural proteins. J. Proteome Res. 8, 5196–211 (2009). 19775189