ATRX Antibody - C-terminal region (ARP47775_P050)

Catalog No: ARP47775_P050

Host: Rabbit
Target Name: ATRX
Sample Type: Jurkat Whole Cell lysates
Antibody Dilution: 1.0ug/mlATRX is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Dog, Pig, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ATRX
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Dog: 88%; Human: 100%; Pig: 93%; Rabbit: 75%
• Peptide Sequence: Synthetic peptide located within the following region: DQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPE
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-ATRX (ARP47775_P050) antibody is Catalog # AAP47775
• Sample Type Confirmation:

  ATRX is strongly supported by BioGPS gene expression data to be expressed in Jurkat

Target Info

• Gene Symbol: ATRX
• Gene Full Name: similar to putative DNA dependent ATPase and helicase
• Alias Symbols: JMS, XH2, XNP, MRX52, RAD54, RAD54L, ZNF-HX
• NCBI Gene Id: 546
• Protein Name: Transcriptional regulator ATRX
• Description of Target: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
• Uniprot ID: P46100-6
• Protein Size (# AA): 1350
• Molecular Weight: 148kDa
• Protein Interactions: SUMO2; SUMO3; RAD51; H3F3A; PRKDC; PML; NBN; MRE11A; HIST1H1C; XRCC6; DAXX; SUPT16H; RAD50; HIST1H4J; HIST2H2BE; HIST1H2BL; HIST1H2AB; XRCC5; TP53; SSRP1; RPA1; RAD9A; RAD1; ZNF512B; UL82; NEK1; BLM; HIST2H3C; ZBED1; UBC; SVIL; CALM1; WRN; HIST1H3A; CBX5;