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Datasheets/Manuals | Printable datasheet for APOBEC3D/F Antibody (OAAF04061) |
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Predicted Species Reactivity | Human|Monkey |
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Product Format | Liquid |
Clonality | Polyclonal |
Host | Rabbit |
Application | Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot |
Reconstitution and Storage | -20°C |
Immunogen | The antiserum was produced against synthesized peptide derived from human APOBEC3D/F. |
Purification | The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen. |
Specificity | APOBEC3D/F antibody detects endogenous levels of total APOBEC3D/F protein. |
Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Dilution | The optimal working dilution should be determined by the end user. |
Application Info | WB: 1:500~1:1000; IHC: 1:50~1:100; ELISA: 1:40000 |
Reference | Dunham I., Nature 402:489-495(1999). Jarmuz A., Genomics 79:285-296(2002). Wedekind J.E., Trends Genet. 19:207-216(2003). |
Gene Symbol | APOBEC3D|APOBEC3F |
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Gene Full Name | apolipoprotein B mRNA editing enzyme catalytic subunit 3D|apolipoprotein B mRNA editing enzyme catalytic subunit 3F |
Alias Symbols | A3D;A3DE;A3F;APOBEC3DE;APOBEC3E;apolipoprotein B editing enzyme catalytic polypeptide-like 3F;apolipoprotein B mRNA editing enzyme cytidine deaminase;apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D;apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3E pseudogene;apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F;ARP6;ARP8;BK150C2.4.MRNA;DNA dC->dU-editing enzyme APOBEC-3D;DNA dC->dU-editing enzyme APOBEC-3F;induced upon T-cell activation;KA6;probable DNA dC->dU-editing enzyme APOBEC-3D. |
NCBI Gene Id | 140564|200316 |
Protein Name | DNA dC->dU-editing enzyme APOBEC-3D|DNA dC->dU-editing enzyme APOBEC-3F |
Description of Target | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.|DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons. |
Uniprot ID | Q8IUX4|Q96AK3 |
Protein Accession # | NP_001006667.1 |
Molecular Weight | 46 kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "APOBEC3D/F Antibody (OAAF04061)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Monkey".
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How long will it take to receive "APOBEC3D/F Antibody (OAAF04061)"?
This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".
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What buffer format is "APOBEC3D/F Antibody (OAAF04061)" provided in?
This item is provided in "Liquid".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "APOBEC3D/F Antibody (OAAF04061)"?
This target may also be called "A3D;A3DE;A3F;APOBEC3DE;APOBEC3E;apolipoprotein B editing enzyme catalytic polypeptide-like 3F;apolipoprotein B mRNA editing enzyme cytidine deaminase;apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D;apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3E pseudogene;apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F;ARP6;ARP8;BK150C2.4.MRNA;DNA dC->dU-editing enzyme APOBEC-3D;DNA dC->dU-editing enzyme APOBEC-3F;induced upon T-cell activation;KA6;probable DNA dC->dU-editing enzyme APOBEC-3D." in publications.
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What is the shipping cost for "APOBEC3D/F Antibody (OAAF04061)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "APOBEC3D/F Antibody (OAAF04061)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "APOBEC3D/F Antibody (OAAF04061)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "46 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "APOBEC3D/F Antibody (OAAF04061)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "APOBEC3D|APOBEC3F"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "APOBEC3D|APOBEC3F"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "APOBEC3D|APOBEC3F"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "APOBEC3D|APOBEC3F"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "APOBEC3D|APOBEC3F"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "APOBEC3D|APOBEC3F"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.