ZFPM1 antibody - middle region (ARP32193_P050)

Catalog#: ARP32193_P050

• Size: 50ug

Human Muscle

• Description of Target: ZFPM1 is a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM1 is an essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. ZFPM1 may be involved in regulation of some genes in gonads. ZFPM1 may also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.
• Gene Symbol: ZFPM1
• Official Gene Full Name: Zinc finger protein, multitype 1
• Alias Symbols: FOG; FOG1; ZNF408; ZNF89A
• Protein Accession#: NP_722520
• Nucleotide Accession#: NM_153813
• Swissprot Id: Q8IX07
• Host: Rabbit
• Clonality: Polyclonal
• Protein Size (# AA): 1006
• Molecular Weight: 105kDa
• Application: WB
• Immunogen: The immunogen for anti-ZFPM1 antibody: synthetic peptide directed towards the middle region of human ZFPM1
• Product Format: Lyophilized powder
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Bovine: 90%; Chicken: 83%
• Peptide Sequence: Synthetic peptide located within the following region: PPPPPPGHAPAPESPRPGSGSGSGPGLAPARSPGPAADGPIDLSKKPRRP
• Blocking Peptide: For anti-ZFPM1 antibody is Catalog # AAP32193 (Previous Catalog # AAPP03166)
• Key Reference: Sugiyama,D., (2008) Blood 111 (4), 1924-1932
• Reconstitution and Storage: Add 50 μl of distilled water. Final anti-ZFPM1 antibody concentration is 1 mg/ml in PBS buffer. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.

Product Protocols: ZFPM1 antibody tested with Human Fetal Muscle Tissue (ARP32193_P050)

Aviva Systems Biology is the original manufacturer of this ZFPM1 antibody (ARP32193_P050)

Click here to view the ZFPM1 antibody Western Blot Protocol

Product Datasheet Link: ZFPM1 antibody (ARP32193_P050)

WB Suggested Anti-ZFPM1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Fetal Muscle

Western Blot image:


Description of Target: ZFPM1 is a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM1 is an essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. ZFPM1 may be involved in regulation of some genes in gonads. ZFPM1 may also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.

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Aviva Systems Biology’s ZFPM1 antibody (ARP32193_P050) has been tested using other cell lysates and tissues. To obtain more data about this antibody please email us at info@avivasysbio.com.

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