Anti-Stat3 (7G8) Antibody (OAED00024)

Catalog No: OAED00024

Size:100UG

Western blot analysis of Stat3 Lane 1: MW; Lane 2: A431; Lane 3:HeLa; Lane 4: NIH-3T3.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Clonality: Monoclonal
• Clone: 7G8
• Host: Mouse
• Application: Western blot
• Reconstitution and Storage: Long Term Storage : -20C
  
• Immunogen: Recombinant full length human Stat3.
• Specificity: Recognizes human, mouse and rat Stat3. Detects a band of ~88kDa by Western blot.
• Formulation: Liquid. In PBS, pH 7.2, containing BSA, 0.09% sodium azide, and 50% glycerol.
• Purity: Protein A affinity purified.
  
• Application Info: Western Blot (1μg/ml, ECL)
  Optimal conditions must be determined individually for each application.

Target Info

• Gene Symbol: STAT3
• Gene Full Name: signal transducer and activator of transcription 3
• Alias Symbols: acute-phase response factor;ADMIO;ADMIO1;APRF;DNA-binding protein APRF;HIES;signal transducer and activator of transcription 3.
• NCBI Gene Id: 6774
• Protein Name: Signal transducer and activator of transcription 3
• Description of Target: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity).
• Uniprot ID: P40763