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100ug
$450.00
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SETDB1 Antibody (OARA02382)

The SET domain is a highly conserved, approximately 150-amino acid motif implicated in the modulation of chromatin structure. It was originally identified as part of a larger conserved region present in the Drosophila trithorax protein and was subsequently identified in the Drosophila Su(var)3-9 and 'Enhancer of zeste' proteins, from which the acronym SET is derived. Studies have suggested that the SET domain may be a signature of proteins that modulate transcriptionally active or repressed chromatin states through chromatin remodeling activities. ESET functions as a histone methyltransferase by methylation of Lys-9 of histone H3.   H3 Lys-9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. ESET shows a nuclear localization and is associated with non-pericentromeric regions of chromatin, and is excluded from nucleoli and islands of condensed chromatin. Although ESET is a widely expressed protein, it is highly expressed in the testis.
Gene Symbol:
SETDB1
Alias Symbols:
Histone lysine N methyltransferase antibody, Histone-lysine N-methyltransferase SETDB1 antibody, KG1T antibody, KIAA00067 antibody, KIAA0067 antibody, KMT1E antibody, Lysine N-methyltransferase 1E antibody
Swissprot Id:
Q15047
Host:
Rabbit
Application:
ELISA, WB, IHC
Clone:
Polyclonal
Immunogen:
The immunogen for anti-SETDB1 antibody: this affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 1058-1075 of human ESET.
Product Format:
Liquid (sterile filtered)
Concentration:
1.17 mg/ml (by UV absorbance at 280 nm)
Datasheets / Downloads:
Printable datasheet for
anti-SETDB1 antibody
- OARA02382
Applications Info:
ELISA: 1:10,000 - 1:50,000 WB: 1:1,000 - 1:2,500 IHC: User Optimized
Additional Information:
Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
:::
Label: Unconjugated
Preservative: 0.01% (w/v) Sodium Azide
Stabilizer: None
Reconstitution and Storage:
Store vial at -20 C prior to opening.   This product is stable for several weeks at 4 C as an undiluted liquid.   Dilute only prior to immediate use.   For extended storage aliquot contents and freeze at -20 C or below.   Avoid cycles of freezing and thawing.   Expiration date is one (1) year from date of opening product.