Anti-SARM (human) (Sarmy-1) Antibody (OAED00366)

Catalog No: OAED00366

Size:100UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid PBS with 10% glycerol and 0.02% sodium azide
• Clonality: Monoclonal
• Clone: Sarmy-1
• Isotype: IgG2b
• Host: Mouse
• Application: Immunoprecipitation
• Reconstitution and Storage: Store short-term at 4°C and long-term at -20°C. Stable for at least 1 year after receipt when stored at -20°C.
  Avoid freeze/thaw cycles.
• Immunogen: Recombinant human SARM (aa 93-292).
• Purification: Purified from concentrated hybridoma tissue culture supernatant
• Concentration: 1 mg/ml
• Application Info: IP: 1:200
  Does not work for Western Blot.
  Optimal dilutions/applications should be determined by the end user.

Target Info

• Gene Symbol: SARM1
• Gene Full Name: sterile alpha and TIR motif containing 1
• Alias Symbols: hSARM1;HsTIR;MyD88-5;NAD(+) hydrolase SARM1;NADase SARM1;NADP(+) hydrolase SARM1;SAM domain-containing protein 2;SAMD2;SARM;sterile alpha and Armadillo repeat protein;sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila;sterile alpha and TIR motif-containing protein 1;sterile alpha motif domain-containing protein 2;tir-1 homolog.
• NCBI Gene Id: 23098
• Protein Name: Sterile alpha and TIR motif-containing protein 1
• Description of Target: Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.
• Uniprot ID: Q6SZW1