Catalog No: OAED00097
Size:50 ug
Price: $219.00
SKU
OAED00097
Availability: Domestic: within 1-2 week delivery | International: 1-2 week
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Datasheets/ManualsPrintable datasheet for Anti-PDK1 Antibody (OAED00097) (OAED00097)
Product Info
Predicted Species ReactivityDog|Human|Monkey|Mouse|Porcine|Rabbit|Rat
Product FormatLiquid. In PBS containing 50% glycerol and 0.09% sodium azide.
ClonalityPolyclonal
HostRabbit
ApplicationWestern blot
Reconstitution and StorageLong Term Storage : -20C
ImmunogenSynthetic peptide corresponding to a portion of human PDK1 (Pyruvate dehydrogenase kinase-1).
PurificationProtein A affinity purified.
SpecificityRecognizes human, mouse, rat, dog, monkey, pig and rabbit PDK1 (Pyruvate dehydrogenase kinase). Detects a band of ~48kDa by Western blot.
Application InfoImmunohistochemistry (paraffin sections)
Western Blot (1:1000, ECL)
Optimal conditions must be determined individually for each application.
ReferencepVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells: W. Krek, et al. ; Genes Dev. 22, 3135 (2008), Application(s): WB using mouse cell lysates, Abstract;
Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels: S.L. Archer, et al. ; Circulation 105, 244 (2002), Application(s): WB using rat samples, Abstract;
Gene SymbolPDK1
Gene Full Namepyruvate dehydrogenase kinase 1
Alias Symbols[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial;mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1;PDH kinase 1;pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial;Pyruvate dehydrogenase kinase isoform 1;pyruvate dehydrogenase kinase, isoenzyme 1.
NCBI Gene Id5163
Protein Name[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
Description of TargetKinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
Uniprot IDQ15118
  1. What is the species homology for "Anti-PDK1 Antibody (OAED00097)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Dog|Human|Monkey|Mouse|Porcine|Rabbit|Rat".

  2. How long will it take to receive "Anti-PDK1 Antibody (OAED00097)"?

    This item is available "Domestic: within 1-2 week delivery | International: 1-2 week".

  3. What buffer format is "Anti-PDK1 Antibody (OAED00097)" provided in?

    This item is provided in "Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "Anti-PDK1 Antibody (OAED00097)"?

    This target may also be called "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial;mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1;PDH kinase 1;pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial;Pyruvate dehydrogenase kinase isoform 1;pyruvate dehydrogenase kinase, isoenzyme 1." in publications.

  5. What is the shipping cost for "Anti-PDK1 Antibody (OAED00097)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "Anti-PDK1 Antibody (OAED00097)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "Anti-PDK1 Antibody (OAED00097)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "Anti-PDK1 Antibody (OAED00097)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "PDK1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "PDK1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "PDK1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "PDK1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "PDK1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "PDK1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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