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Datasheets/Manuals | Printable datasheet for Anti-DR6 (human) (Luke-1) Antibody (OAED00316) (OAED00316) |
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Predicted Species Reactivity | Human |
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Clonality | Monoclonal |
Clone | Luke-1 |
Isotype | IgG2a |
Host | Rat |
Application | Flow cytometry |
Reconstitution and Storage | Long Term Storage : -20C Short Term Storage : +4C Handling : Stable for at least 1 year after receipt when stored as recommended. |
Immunogen | Recombinant human DR6 (death receptor-6) (aa 42-335) (Prod. No. ALX-522-019). |
Concentration | 1mg/ml |
Specificity | Recognizes human DR6. |
Source | Purified from concentrated hybridoma tissue culture supernatant. |
Formulation | Liquid. In PBS containing 0.02% sodium azide. |
Purity | ≥95% (SDS-PAGE) |
Application Info | Flow Cytometry |
Reference | Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice: J. Liu, et al.; Immunity 15, 23 (2001), Abstract; Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice : H. Zhao, et al.; J. Exp. Med. 194, 1441 (2001), Abstract; Full Text Identification and functional characterization of DR6, a novel death domain-containing TNF receptor : G. Pan, et al.; FEBS Lett 431, 351 (1998), Abstract; |
Gene Symbol | TNFRSF21 |
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Gene Full Name | TNF receptor superfamily member 21 |
Alias Symbols | BM-018;CD358;death receptor 6;DR6;TNFR-related death receptor 6;tumor necrosis factor receptor superfamily member 21. |
NCBI Gene Id | 27242 |
Protein Name | Tumor necrosis factor receptor superfamily member 21 |
Description of Target | Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. |
Uniprot ID | O75509 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "Anti-DR6 (human) (Luke-1) Antibody (OAED00316)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "Anti-DR6 (human) (Luke-1) Antibody (OAED00316)"?
This item is available "Domestic: within 1-2 week delivery | International: 1-2 week".
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What buffer format is "Anti-DR6 (human) (Luke-1) Antibody (OAED00316)" provided in?
This item is provided in "".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "Anti-DR6 (human) (Luke-1) Antibody (OAED00316)"?
This target may also be called "BM-018;CD358;death receptor 6;DR6;TNFR-related death receptor 6;tumor necrosis factor receptor superfamily member 21." in publications.
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What is the shipping cost for "Anti-DR6 (human) (Luke-1) Antibody (OAED00316)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "Anti-DR6 (human) (Luke-1) Antibody (OAED00316)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "Anti-DR6 (human) (Luke-1) Antibody (OAED00316)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "Anti-DR6 (human) (Luke-1) Antibody (OAED00316)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "TNFRSF21"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "TNFRSF21"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "TNFRSF21"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "TNFRSF21"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "TNFRSF21"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "TNFRSF21"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.