Caspase-3 Antibody (OAED00052)

Catalog No: OAED00052

Size:50 ug

Western Blot Analysis of Caspase-3, pAb: Lane 1:MW Marker; Lane 2: HeLa Cell Lysate; Lane 3: Jurkat Cell Lysate; Lane 4: Jurkat + Staurosporine

Product Info

• Predicted Species Reactivity: Bovine|Chicken|Dog|Guinea Pig|Hamster|Human|Monkey|Mouse|Porcine|Rabbit|Rat|Sheep|Xenopus
• Product Format: Liquid. Antiserum.
• Clonality: Polyclonal
• Host: Rabbit
• Application: Western blot
• Reconstitution and Storage: Long term storage at -20°C. Avoid freeze/thaw cycles.
• Immunogen: Synthetic peptide corresponding to a portion of human caspase-3 . The sequence differs from rat caspase-3 by 1 aa and from mouse by 2 aa.
• Intended Use: For research use only.
• Application Info: WB: 1:5000
  
• Reference: Rapid cold-hardening protects Drosophila melanogaster from cold-induced apoptosis: R.E. Lee, et al. ; Apoptosis 12, 1183 (2007), Application(s): WB using drosophila cell lysates, Abstract;
  

Target Info

• Gene Symbol: CASP3
• Gene Full Name: caspase 3
• Alias Symbols: apopain;CASP-3;caspase 3, apoptosis-related cysteine peptidase;caspase 3, apoptosis-related cysteine protease;caspase-3;CPP32;CPP-32;CPP32B;cysteine protease CPP32;PARP cleavage protease;procaspase3;protein Yama;SCA-1;SREBP cleavage activity 1.
• NCBI Gene Id: 836
• Protein Name: Caspase-3
• Description of Target: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
• Uniprot ID: P42574
• Molecular Weight: ~36 kDa