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Datasheets/Manuals | Printable datasheet for anti-ACVR1 (ARP45039_P050) antibody |
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Tested Species Reactivity | Human, Mouse |
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Predicted Species Reactivity | Human, Mouse, Rat, Cow, Goat, Guinea Pig, Horse, Pig, Rabbit |
Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Clonality | Polyclonal |
Host | Rabbit |
Application | WB |
Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human ACVR1 |
Purification | Affinity Purified |
Predicted Homology Based on Immunogen Sequence | Cow: 100%; Goat: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100% |
Peptide Sequence | Synthetic peptide located within the following region: EGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSP |
Concentration | 0.5 mg/ml |
Blocking Peptide | For anti-ACVR1 (ARP45039_P050) antibody is Catalog # AAP45039 (Previous Catalog # AAPP12327) |
Reference | Kariyawasam,H.H., (2008) Am. J. Respir. Crit. Care Med. 177 (10), 1074-1081 |
Gene Symbol | ACVR1 |
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Gene Full Name | Activin A receptor, type I |
Alias Symbols | FOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2 |
NCBI Gene Id | 90 |
Protein Name | Activin receptor type-1 |
Description of Target | Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 is activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. |
Uniprot ID | Q04771 |
Protein Accession # | NP_001096 |
Nucleotide Accession # | NM_001105 |
Protein Size (# AA) | 509 |
Molecular Weight | 55kDa |
Protein Interactions | UBC; USP15; BMPR1A; ACVR1; INHBA; ACVR2A; PEG10; SMAD6; SMAD7; BAMBI; SMURF1; IGSF1; TSC22D1; TGFBR1; DCAF6; FGD6; FCHO1; PLEK; TTC17; RHEBL1; WDR61; RASL12; RASD2; PLEKHJ1; CDK14; NEK8; DUSP13; NUAK2; FKBP4; RAB6B; RAB17; UBXN1; FBXO30; RHOJ; PLEKHB1; UB |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "ACVR1 Antibody - N-terminal region (ARP45039_P050)"?
The tested species reactivity for this item is "Human, Mouse". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Goat, Guinea Pig, Horse, Pig, Rabbit".
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How long will it take to receive "ACVR1 Antibody - N-terminal region (ARP45039_P050)"?
This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".
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What buffer format is "ACVR1 Antibody - N-terminal region (ARP45039_P050)" provided in?
This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "ACVR1 Antibody - N-terminal region (ARP45039_P050)"?
This target may also be called "FOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2" in publications.
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What is the shipping cost for "ACVR1 Antibody - N-terminal region (ARP45039_P050)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "ACVR1 Antibody - N-terminal region (ARP45039_P050)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "ACVR1 Antibody - N-terminal region (ARP45039_P050)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "55kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "ACVR1 Antibody - N-terminal region (ARP45039_P050)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "ACVR1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "ACVR1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "ACVR1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "ACVR1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "ACVR1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "ACVR1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.